Gene Symbol | USP11 |
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Entrez Gene | 8237 |
Alt Symbol | UHX1 |
Species | Human |
Gene Type | protein-coding |
Description | ubiquitin specific peptidase 11 |
Other Description | deubiquitinating enzyme 11|ubiquitin carboxyl-terminal hydrolase 11|ubiquitin carboxyl-terminal hydrolase, X-linked|ubiquitin thioesterase 11|ubiquitin thiolesterase 11|ubiquitin-specific processing protease 11|ubiquitin-specific-processing protease 11 |
Swissprots | Q8IUG6 P51784 B2RTX1 Q9BWE1 |
Accessions | CBX47606 EAW59288 EAW59289 P51784 AB073597 BAC20463 AK055588 BAG51540 AK098394 AK294635 BAG57814 BC000350 AAH00350 BC063668 AAH63668 BC073960 BC140849 AAI40850 BQ022385 DQ581100 U44839 AAC50450 XM_005272674 XP_005272731 XM_011543988 XP_011542290 NM_004651 NP_004642 |
Function | Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. {ECO:0000269|PubMed:15314155, ECO:0000269|PubMed:17897950, ECO:0000269|PubMed:18408009, ECO:0000269|PubMed:19874889, ECO:0000269|PubMed:20233726}. |
Subcellular Location | Nucleus. Cytoplasm. Note=Predominantly nuclear. Associates with chromatin. |
USP11 CRISPR/Cas9 KO Plasmid (h) - sc-403368 from Santa Cruz Biotechnology
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USP11 HDR Plasmid (h) - sc-403368-HDR from Santa Cruz Biotechnology
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USP11 Double Nickase Plasmid (h) - sc-403368-NIC from Santa Cruz Biotechnology
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USP11 Double Nickase Plasmid (h2) - sc-403368-NIC-2 from Santa Cruz Biotechnology
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USP11 CRISPR Activation Plasmid (h) - sc-403368-ACT from Santa Cruz Biotechnology
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USP11 CRISPR Activation Plasmid (h2) - sc-403368-ACT-2 from Santa Cruz Biotechnology
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USP11 Lentiviral Activation Particles (h) - sc-403368-LAC from Santa Cruz Biotechnology
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USP11 Lentiviral Activation Particles (h2) - sc-403368-LAC-2 from Santa Cruz Biotechnology
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USP11 siRNA (h) - sc-63193 from Santa Cruz Biotechnology
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USP11 shRNA Plasmid (h) - sc-63193-SH from Santa Cruz Biotechnology
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USP11 shRNA (h) Lentiviral Particles - sc-63193-V from Santa Cruz Biotechnology
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USP11 RNAi - H00008237-R01 from Novus Biologicals
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MISSION® esiRNA - EHU025071 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22557 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22557 from Sigma-Aldrich
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USP11 siRNA (Human) - CRH5409 from Cohesion Biosciences
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USP11 - MBS8232420 from MyBioSource
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shRNA set against Human USP11 (NM_004651.3) - SHH441224 from Creative biogene
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shRNA set against Human USP11(NM_004651.3) - SHL117210 from Creative biogene
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USP11 shRNA Plasmid (Human) - CHH5409 from Cohesion Biosciences
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USP11 miRNA 3'UTR clone - MiUTR1H-11047 from Creative biogene
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