| Gene Symbol |
USP11
|
| Entrez Gene |
8237
|
| Alt Symbol |
UHX1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin specific peptidase 11
|
| Other Description |
deubiquitinating enzyme 11|ubiquitin carboxyl-terminal hydrolase 11|ubiquitin carboxyl-terminal hydrolase, X-linked|ubiquitin thioesterase 11|ubiquitin thiolesterase 11|ubiquitin-specific processing protease 11|ubiquitin-specific-processing protease 11
|
| Swissprots |
Q8IUG6 P51784 B2RTX1 Q9BWE1
|
| Accessions |
CBX47606 EAW59288 EAW59289 P51784 AB073597 BAC20463 AK055588 BAG51540 AK098394 AK294635 BAG57814 BC000350 AAH00350 BC063668 AAH63668 BC073960 BC140849 AAI40850 BQ022385 DQ581100 U44839 AAC50450 XM_005272674 XP_005272731 XM_011543988 XP_011542290 NM_004651 NP_004642
|
| Function |
Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. {ECO:0000269|PubMed:15314155, ECO:0000269|PubMed:17897950, ECO:0000269|PubMed:18408009, ECO:0000269|PubMed:19874889, ECO:0000269|PubMed:20233726}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Predominantly nuclear. Associates with chromatin.
|