Gene Symbol | USP11 |
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Entrez Gene | 8237 |
Alt Symbol | UHX1 |
Species | Human |
Gene Type | protein-coding |
Description | ubiquitin specific peptidase 11 |
Other Description | deubiquitinating enzyme 11|ubiquitin carboxyl-terminal hydrolase 11|ubiquitin carboxyl-terminal hydrolase, X-linked|ubiquitin thioesterase 11|ubiquitin thiolesterase 11|ubiquitin-specific processing protease 11|ubiquitin-specific-processing protease 11 |
Swissprots | Q8IUG6 P51784 B2RTX1 Q9BWE1 |
Accessions | CBX47606 EAW59288 EAW59289 P51784 AB073597 BAC20463 AK055588 BAG51540 AK098394 AK294635 BAG57814 BC000350 AAH00350 BC063668 AAH63668 BC073960 BC140849 AAI40850 BQ022385 DQ581100 U44839 AAC50450 XM_005272674 XP_005272731 XM_011543988 XP_011542290 NM_004651 NP_004642 |
Function | Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. {ECO:0000269|PubMed:15314155, ECO:0000269|PubMed:17897950, ECO:0000269|PubMed:18408009, ECO:0000269|PubMed:19874889, ECO:0000269|PubMed:20233726}. |
Subcellular Location | Nucleus. Cytoplasm. Note=Predominantly nuclear. Associates with chromatin. |
Human USP11 peptide - ab23087 from Abcam
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Human USP11 protein fragment - ab159977 from Abcam
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USP11 Antibody Blocking Peptide - LS-E25551 from LifeSpan Bioscience
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USP11 Antibody Blocking Peptide - LS-E6886 from LifeSpan Bioscience
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Recombinant Human USP11 Protein - H00008237-Q01 from Novus Biologicals
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USP11-Antibody-N-term-N20-Blocking-peptide - BP2139a from Abgent, a WuXi AppTec company
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USP11 blocking peptide - GTX25269-PEP from GeneTex
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USP11 peptide - orb218129 from Biorbyt
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USP11 Immunizing peptide - orb17766 from Biorbyt
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USP11 Blocking Peptide - abx063460 from Abbexa
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USP11 Peptide - AC21-0380-P from Abcore
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USP11 - H00008237-Q01-10 from Acris Antibodies
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USP11 - H00008237-Q01-25 from Acris Antibodies
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USP11 Peptide - 46-555P from ProSci
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USP11 fusion protein - ag0296 from Proteintech Group
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USP11 fusion protein - ag19058 from Proteintech Group
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USP11 fusion protein - ag17829 from Proteintech Group
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USP11 Blocking Peptide - CBP2266 from Cohesion Biosciences
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USP11 Peptide - BS5973P from Bioworld Technology
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Recombinant Human Ubiquitin carboxyl-terminal hydrolase 11(USP11) ,partial - CSB-YP025698HU CSB-EP025698HU CSB-BP025698HU CSB-MP025698HU from Cusabio
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Human USP11 full length protein - ab206019 from Abcam
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USP11/UHX1, Peptide - MBS425225 from MyBioSource
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USP11 Recombinant Protein Antigen - NBP1-80640PEP from Novus Biologicals
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USP11 Recombinant Protein Antigen - NBP1-80639PEP from Novus Biologicals
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Recombinant Human His6-USP11 Protein, CF - E-602 from R&D Systems
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