Gene Symbol | SERPINB1 |
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Entrez Gene | 1992 |
Alt Symbol | EI, ELANH2, HEL57, LEI, M/NEI, MNEI, PI-2, PI2 |
Species | Human |
Gene Type | protein-coding |
Description | serpin peptidase inhibitor, clade B (ovalbumin), member 1 |
Other Description | epididymis luminal protein 57|leukocyte elastase inhibitor|peptidase inhibitor 2|protease inhibitor 2 (anti-elastase), monocyte/neutrophil derived|serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1 |
Swissprots | P30740 Q9UDF8 B4DNT0 Q53FB9 Q5W0E1 A8K5L2 |
Accessions | AAC31394 EAW55089 EAW55090 P30740 AK223370 BAD97090 AK291327 BAF84016 AK298044 BAG60342 AK304641 BAG65420 AK309765 AK312973 AW451326 BC009015 AAH09015 BI521531 BM785367 BM823453 BT006928 AAP35574 BU942473 EU794624 ACJ13678 M93056 XM_011514333 XP_011512635 XM_011514334 XP_011512636 XM_011514335 XP_011512637 NM_030666 NP_109591 NR_073111 NR_073112 |
Function | Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also functions as a potent intracellular inhibitor of granzyme H. {ECO:0000269|PubMed:11747453}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Cytoplasmic granule {ECO:0000269|PubMed:23269243}. |
Top Pathways | Amoebiasis |
SerpinB1 CRISPR/Cas9 KO Plasmid (h) - sc-402083 from Santa Cruz Biotechnology
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SerpinB1 HDR Plasmid (h) - sc-402083-HDR from Santa Cruz Biotechnology
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SerpinB1 Double Nickase Plasmid (h) - sc-402083-NIC from Santa Cruz Biotechnology
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SerpinB1 Double Nickase Plasmid (h2) - sc-402083-NIC-2 from Santa Cruz Biotechnology
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SerpinB1 CRISPR Activation Plasmid (h) - sc-402083-ACT from Santa Cruz Biotechnology
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SerpinB1 CRISPR Activation Plasmid (h2) - sc-402083-ACT-2 from Santa Cruz Biotechnology
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SerpinB1 Lentiviral Activation Particles (h) - sc-402083-LAC from Santa Cruz Biotechnology
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SerpinB1 Lentiviral Activation Particles (h2) - sc-402083-LAC-2 from Santa Cruz Biotechnology
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SerpinB1 siRNA (h) - sc-45371 from Santa Cruz Biotechnology
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SerpinB1 shRNA Plasmid (h) - sc-45371-SH from Santa Cruz Biotechnology
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SerpinB1 shRNA (h) Lentiviral Particles - sc-45371-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU027701 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19137 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19137 from Sigma-Aldrich
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SERPINB1 siRNA (Human) - CRH1376 from Cohesion Biosciences
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SERPINB1 - MBS8202327 from MyBioSource
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shRNA set against Human SERPINB1 (NM_030666.3) - SHH405084 from Creative biogene
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Human SERPINB1 siRNA - orb261878 from Biorbyt
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SERPINB1 shRNA Plasmid (Human) - CHH1376 from Cohesion Biosciences
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SERPINB1 miRNA 3'UTR clone - MiUTR3H-00700 from Creative biogene
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