Gene Symbol |
SERPINB1
|
Entrez Gene |
1992
|
Alt Symbol |
EI, ELANH2, HEL57, LEI, M/NEI, MNEI, PI-2, PI2
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
serpin peptidase inhibitor, clade B (ovalbumin), member 1
|
Other Description |
epididymis luminal protein 57|leukocyte elastase inhibitor|peptidase inhibitor 2|protease inhibitor 2 (anti-elastase), monocyte/neutrophil derived|serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1
|
Swissprots |
P30740 Q9UDF8 B4DNT0 Q53FB9 Q5W0E1 A8K5L2
|
Accessions |
AAC31394 EAW55089 EAW55090 P30740 AK223370 BAD97090 AK291327 BAF84016 AK298044 BAG60342 AK304641 BAG65420 AK309765 AK312973 AW451326 BC009015 AAH09015 BI521531 BM785367 BM823453 BT006928 AAP35574 BU942473 EU794624 ACJ13678 M93056 XM_011514333 XP_011512635 XM_011514334 XP_011512636 XM_011514335 XP_011512637 NM_030666 NP_109591 NR_073111 NR_073112
|
Function |
Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also functions as a potent intracellular inhibitor of granzyme H. {ECO:0000269|PubMed:11747453}.
|
Subcellular Location |
Cytoplasm {ECO:0000250}. Cytoplasmic granule {ECO:0000269|PubMed:23269243}.
|
Top Pathways |
Amoebiasis
|