| Gene Symbol | Foxp3 |
|---|---|
| Entrez Gene | 20371 |
| Alt Symbol | JM2, scurfin, sf |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | forkhead box P3 |
| Other Description | forkhead box protein P3|scurfy |
| Swissprots | Q99JB6 |
| Accessions | AAG53608 EDL33899 EDL33900 Q99JB6 AB673115 AF277991 AAG53605 AF277992 AAG53606 AK157447 BAE34089 AK210240 AK212556 AK216372 AY357712 AAR11305 AY357713 AAR11306 BC132333 AAI32334 BC132335 AAI32336 DQ387959 ABD52722 KF471319 AHA56672 NM_001199347 NP_001186276 NM_001199348 NP_001186277 NM_054039 NP_473380 |
| Function | Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon- gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone ace |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:18368049}. Cytoplasm {ECO:0000250|UniProtKB:Q9BZS1}. Note=Predominantly expressed in the cytoplasm in activated conventional T-cells whereas predominantly expressed in the nucleus in regulatory T-cells (Treg) (By similarity). The 41 kDa form derived by proteolytic processing is found exclusively in the chromatin fraction of activated Treg cells. {ECO:0000250|UniProtKB:Q9BZS1, ECO:0000269|PubMed:19117830}. |
| Tissue Specificity | High level of expression in thymus and spleen. |
| Top Pathways | Inflammatory bowel disease (IBD) |
FOXP3 CRISPR/Cas9 KO Plasmid (m) - sc-422896 from Santa Cruz Biotechnology
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FOXP3 HDR Plasmid (m) - sc-422896-HDR from Santa Cruz Biotechnology
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FOXP3 Double Nickase Plasmid (m) - sc-422896-NIC from Santa Cruz Biotechnology
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FOXP3 Double Nickase Plasmid (m2) - sc-422896-NIC-2 from Santa Cruz Biotechnology
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FOXP3 CRISPR Activation Plasmid (m) - sc-422896-ACT from Santa Cruz Biotechnology
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FOXP3 CRISPR Activation Plasmid (m2) - sc-422896-ACT-2 from Santa Cruz Biotechnology
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FOXP3 Lentiviral Activation Particles (m) - sc-422896-LAC from Santa Cruz Biotechnology
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FOXP3 Lentiviral Activation Particles (m2) - sc-422896-LAC-2 from Santa Cruz Biotechnology
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FOXP3 siRNA (m) - sc-45646 from Santa Cruz Biotechnology
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FOXP3 shRNA Plasmid (m) - sc-45646-SH from Santa Cruz Biotechnology
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FOXP3 shRNA (m) Lentiviral Particles - sc-45646-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU058321 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN31526 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND31526 from Sigma-Aldrich
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FOXP3 siRNA (Mouse) - CRM3679 from Cohesion Biosciences
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FOXP3 - MBS8238463 from MyBioSource
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shRNA set against Mouse FOXP3 (NM_054039.2) - SHH296829 from Creative biogene
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FOXP3 CRISPR/Cas9 KO Plasmid (m2) - sc-422896-KO-2 from Santa Cruz Biotechnology
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FOXP3 HDR Plasmid (m2) - sc-422896-HDR-2 from Santa Cruz Biotechnology
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Mouse FOXP3 siRNA - orb283155 from Biorbyt
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FOXP3 shRNA Plasmid (Mouse) - CHM3679 from Cohesion Biosciences
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