Foxp3

Gene Symbol	Foxp3
Entrez Gene	20371
Alt Symbol	JM2, scurfin, sf
Species	Mouse
Gene Type	protein-coding
Description	forkhead box P3
Other Description	forkhead box protein P3|scurfy
Swissprots	Q99JB6
Accessions	AAG53608 EDL33899 EDL33900 Q99JB6 AB673115 AF277991 AAG53605 AF277992 AAG53606 AK157447 BAE34089 AK210240 AK212556 AK216372 AY357712 AAR11305 AY357713 AAR11306 BC132333 AAI32334 BC132335 AAI32336 DQ387959 ABD52722 KF471319 AHA56672 NM_001199347 NP_001186276 NM_001199348 NP_001186277 NM_054039 NP_473380
Function	Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon- gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone ace
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:18368049}. Cytoplasm {ECO:0000250|UniProtKB:Q9BZS1}. Note=Predominantly expressed in the cytoplasm in activated conventional T-cells whereas predominantly expressed in the nucleus in regulatory T-cells (Treg) (By similarity). The 41 kDa form derived by proteolytic processing is found exclusively in the chromatin fraction of activated Treg cells. {ECO:0000250|UniProtKB:Q9BZS1, ECO:0000269|PubMed:19117830}.
Tissue Specificity	High level of expression in thymus and spleen.
Top Pathways	Inflammatory bowel disease (IBD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Mouse FOXP3 Protein - abx066689 from Abbexa Category Protein Source E.coli Species Mouse

FOXP3 Peptide - AC21-0555-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

FOXP3 control peptide - AP10074CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

Forkhead Box Protein P3 (FOXP3), Mouse - 20-8102 from ARP American Research Products Category Protein Prices $495.00 Sizes 50 µg Source E.coli Species Mouse

FOXP3 Peptide - 45-626P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse

Recombinant Forkhead Box Protein P3 (FOXP3) - RPB877Mu01 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Forkhead Box Protein P3 (FOXP3) - RPB877Mu02 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Mouse Forkhead box protein P3(Foxp3) - CSB-YP857473MO CSB-EP857473MO CSB-BP857473MO CSB-MP857473MO from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Mouse

FOXP3, Peptide - MBS843595 from MyBioSource Category Peptide Prices $165.00 Sizes 50 µg

FOXP3/Scurfin, Peptide - MBS425845 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Mouse, Rat

Forkhead box protein P3 (Foxp3), Recombinant Protein - MBS1372821 from MyBioSource Category Protein Prices $1,205.00, $1,205.00, $1,425.00, $1,425.00, $1,945.00, $1,945.00, $2,410.00, $2,410.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Mouse

Forkhead Box Protein P3 (FOXP3), Recombinant Protein - MBS2009554 from MyBioSource Category Protein Prices $185.00, $385.00, $590.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Mouse

FOXP3 Recombinant Protein (OPCD03301) - OPCD03301 from Aviva Systems Biology Category Protein Source E.coli Species Mouse

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