| Gene Symbol |
Foxp3
|
| Entrez Gene |
20371
|
| Alt Symbol |
JM2, scurfin, sf
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
forkhead box P3
|
| Other Description |
forkhead box protein P3|scurfy
|
| Swissprots |
Q99JB6
|
| Accessions |
AAG53608 EDL33899 EDL33900 Q99JB6 AB673115 AF277991 AAG53605 AF277992 AAG53606 AK157447 BAE34089 AK210240 AK212556 AK216372 AY357712 AAR11305 AY357713 AAR11306 BC132333 AAI32334 BC132335 AAI32336 DQ387959 ABD52722 KF471319 AHA56672 NM_001199347 NP_001186276 NM_001199348 NP_001186277 NM_054039 NP_473380
|
| Function |
Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon- gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone ace
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:18368049}. Cytoplasm {ECO:0000250|UniProtKB:Q9BZS1}. Note=Predominantly expressed in the cytoplasm in activated conventional T-cells whereas predominantly expressed in the nucleus in regulatory T-cells (Treg) (By similarity). The 41 kDa form derived by proteolytic processing is found exclusively in the chromatin fraction of activated Treg cells. {ECO:0000250|UniProtKB:Q9BZS1, ECO:0000269|PubMed:19117830}.
|
| Tissue Specificity |
High level of expression in thymus and spleen.
|
| Top Pathways |
Inflammatory bowel disease (IBD)
|