Foxp3

Gene Symbol	Foxp3
Entrez Gene	20371
Alt Symbol	JM2, scurfin, sf
Species	Mouse
Gene Type	protein-coding
Description	forkhead box P3
Other Description	forkhead box protein P3|scurfy
Swissprots	Q99JB6
Accessions	AAG53608 EDL33899 EDL33900 Q99JB6 AB673115 AF277991 AAG53605 AF277992 AAG53606 AK157447 BAE34089 AK210240 AK212556 AK216372 AY357712 AAR11305 AY357713 AAR11306 BC132333 AAI32334 BC132335 AAI32336 DQ387959 ABD52722 KF471319 AHA56672 NM_001199347 NP_001186276 NM_001199348 NP_001186277 NM_054039 NP_473380
Function	Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon- gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone ace
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:18368049}. Cytoplasm {ECO:0000250|UniProtKB:Q9BZS1}. Note=Predominantly expressed in the cytoplasm in activated conventional T-cells whereas predominantly expressed in the nucleus in regulatory T-cells (Treg) (By similarity). The 41 kDa form derived by proteolytic processing is found exclusively in the chromatin fraction of activated Treg cells. {ECO:0000250|UniProtKB:Q9BZS1, ECO:0000269|PubMed:19117830}.
Tissue Specificity	High level of expression in thymus and spleen.
Top Pathways	Inflammatory bowel disease (IBD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Anti-FOXP3 antibody - ab15590 from Abcam Prices $387.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

FoxP3 Antibody - NB100-39002 from Novus Biologicals Prices $129.00, $349.00 Sizes 25 µl, 100 µl Host Rabbit Clonality Polyclonal

FoxP3 Antibody - NB600-243 from Novus Biologicals Prices $299.00 Sizes 100 µg Host Goat Clonality Polyclonal

FoxP3 Antibody - NBP1-18319 from Novus Biologicals Prices $329.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

FoxP3 Antibody [Alexa Fluor (R) 700] - NB100-39002AF700 from Novus Biologicals Prices $289.00 Sizes 100 tests Host Rabbit Clonality Polyclonal

FoxP3 Antibody [Alexa Fluor (R) 647] - NB100-39002AF647 from Novus Biologicals Prices $339.00 Sizes 100 tests Host Rabbit Clonality Polyclonal

FoxP3 Antibody [Alexa Fluor (R) 488] - NB100-39002AF488 from Novus Biologicals Prices $319.00 Sizes 100 tests Host Rabbit Clonality Polyclonal

FoxP3 Antibody [Alexa Fluor (R) 405] - NB100-39002AF405 from Novus Biologicals Prices $359.00 Sizes 100 tests Host Rabbit Clonality Polyclonal

FoxP3 Antibody [DyLight 650] - NB100-39002C from Novus Biologicals Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

FoxP3 Antibody [DyLight 488] - NB100-39002G from Novus Biologicals Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

FoxP3 Antibody [Biotin] - NB100-39002B from Novus Biologicals Prices $309.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

FoxP3 Antibody [HRP] - NB100-39002H from Novus Biologicals Prices $349.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

FoxP3 Antibody [DyLight 550] - NB100-39002R from Novus Biologicals Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

FoxP3 Antibody [PE] - NB100-39002PE from Novus Biologicals Host Rabbit Clonality Polyclonal

Anti-Foxp3 (C-terminal) antibody produced in rabbit - SAB2700362 from Sigma-Aldrich Prices $326.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

FOXP3 Antibody (OAAD00419) - OAAD00419 from Aviva Systems Biology Prices $290.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2A11G9, 2A11C2

FOXP3 Antibody (OAAD00447) - OAAD00447 from Aviva Systems Biology Prices $290.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 6H3C5H3

Foxp3 Antibody - N-terminal region (ARP37438_P050) - ARP37438_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

FOXP3--Scurfin-Mouse-Antibody-C-Term - AF2411a from Abgent, a WuXi AppTec company Prices $335.00 Sizes 100 µg Host Goat Clonality Polyclonal

Goat-Anti-Foxp3-Antibody - AF4139a from Abgent, a WuXi AppTec company Prices $325.00 Sizes 100 µg Host Goat Clonality Polyclonal

Foxp3 antibody - orb66874 from Biorbyt Prices $425.00 Sizes 100 μl Host Rabbit Clonality Polyclonal

Foxp3 antibody - orb66675 from Biorbyt Prices $425.00 Sizes 100 μl Host Mouse Clonality Monoclonal Clone 9B3

Foxp3 antibody - orb66676 from Biorbyt Prices $425.00 Sizes 100 μl Host Mouse Clonality Monoclonal Clone 5F4

FOXP3 Polyclonal Antibody (OABB00529) - OABB00529 from Aviva Systems Biology Prices $255.00 Sizes 100 µg Clonality Polyclonal

Goat Anti-FOXP3 / Scurfin (Mouse) Antibody (OAEB00854) - OAEB00854 from Aviva Systems Biology Prices $289.00 Sizes 100 µg Host Goat Clonality Polyclonal

Search more