Foxp3

Gene Symbol	Foxp3
Entrez Gene	20371
Alt Symbol	JM2, scurfin, sf
Species	Mouse
Gene Type	protein-coding
Description	forkhead box P3
Other Description	forkhead box protein P3|scurfy
Swissprots	Q99JB6
Accessions	AAG53608 EDL33899 EDL33900 Q99JB6 AB673115 AF277991 AAG53605 AF277992 AAG53606 AK157447 BAE34089 AK210240 AK212556 AK216372 AY357712 AAR11305 AY357713 AAR11306 BC132333 AAI32334 BC132335 AAI32336 DQ387959 ABD52722 KF471319 AHA56672 NM_001199347 NP_001186276 NM_001199348 NP_001186277 NM_054039 NP_473380
Function	Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon- gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone ace
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:18368049}. Cytoplasm {ECO:0000250|UniProtKB:Q9BZS1}. Note=Predominantly expressed in the cytoplasm in activated conventional T-cells whereas predominantly expressed in the nucleus in regulatory T-cells (Treg) (By similarity). The 41 kDa form derived by proteolytic processing is found exclusively in the chromatin fraction of activated Treg cells. {ECO:0000250|UniProtKB:Q9BZS1, ECO:0000269|PubMed:19117830}.
Tissue Specificity	High level of expression in thymus and spleen.
Top Pathways	Inflammatory bowel disease (IBD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

FoxP3 Flow Assay Kit - NBP2-29493 from Novus Biologicals Category Flow Assay Prices $399.00 Sizes 1 kit

FoxP3 Flow Assay Kit - NBP2-29488 from Novus Biologicals Category Flow Assay Prices $399.00 Sizes 1 kit

Forkhead Box Protein P3 (FOXP3), Mouse, ELISA Kit - SEB877Mu from ARP American Research Products Category ELISA Kit Prices $704.00 Sizes 96 t Sensitivity 0.122ng/mL Range 0.312-20ng/mL

Forkhead box protein P3, Foxp3, Mouse, ELISA Kit - E1877m from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.25-16 ng/mL

Alexa Fluor® 488 anti-mouse/rat/human FOXP3 Flow Kit - 320017 from Biolegend Category Flow Assay Prices $295.00 Sizes 25 tests

Alexa Fluor® 647 anti-mouse/rat/human FOXP3 Flow Kit - 320021 from Biolegend Category Flow Assay Prices $295.00 Sizes 25 tests

PE anti-mouse/rat/human FOXP3 Flow Kit - 320019 from Biolegend Category Flow Assay Prices $325.00 Sizes 25 tests

Human Treg Flow™ Kit (FOXP3 Alexa Fluor® 488/CD4 PE-Cy5/CD25 PE) - 320022 from Biolegend Category Flow Assay Prices $450.00 Sizes 25 tests

Mouse Treg Flow™ Kit (FOXP3 Alexa Fluor® 488/CD4 APC/CD25 PE) - 320018 from Biolegend Category Flow Assay Prices $450.00 Sizes 25 tests

Mouse FOXP3 ELISA Kit - MF0126 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Mouse FOXP3(Forkhead Box Protein P3) ELISA Kit - E-EL-M0513 from Elabscience Category ELISA Kit Sensitivity 0.19 ng/mL Range 0.31—20 ng/mL

Mouse Regulatory T Cell Staining Kit #3 - 88-8115 from eBioscience Prices $449.00 Sizes kit

Mouse Forkhead Box Protein P3 ELISA - E03F0119 from BlueGene Biotech Category ELISA Kit Sensitivity 0.1 ng/mL

ELISA Kit for Forkhead Box Protein P3 (FOXP3) - SEB877Mu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.122ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Mouse FOXP3(Forkhead Box Protein P3) ELISA Kit - E-EL-M0513 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.19 ng/mL Range 0.31~20 ng/mL

Mouse FOXP3 ELISA Kit - abx154036 from Abbexa Category ELISA Kit Sensitivity 0.122 ng/ml Range 0.313 ng/ml - 20 ng/ml

Forkhead Box Protein P3 (FOXP3), Mouse, ELISA Kit - DL-FOXP3-Mu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Range 0.312-20 ng/mL

Mouse FOXP3 ELISA Kit - abx572251 from Abbexa Category ELISA Kit Sensitivity 0.122 ng/ml Range 0.313 ng/ml - 20 ng/ml

Foxp3 - EKM1382 from Nordic BioSite Sensitivity 0.188ng/ml Range 0.313-20ng/ml

Mouse Foxp3 ELISA Kit - E053337 from Biobool Category ELISA Kit

FOXP3 ELISA Kit (Mouse) (OKEH03418) - OKEH03418 from Aviva Systems Biology Category ELISA Kit Prices $425.00 Sizes 96 wells Sensitivity < 0.12 ng/mL Range 0.25 - 16 ng/mL

Mouse FOXP3 ELISA Kit - EMF0126 from ABclonal Category ELISA Kit Prices $495.00 Sizes 96 t

Mouse Forkhead box protein P3 ELISA Kit - EK4044 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Sensitivity less than 0.1ng/mL Range 0.312-20 ng/mL

Forkhead box protein P3, ELISA Kit - MBS9427873 from MyBioSource Category ELISA Kit Prices $555.00 Sizes 96 tests Range 0.25-16 ng/mL

Forkhead box protein P3, ELISA Kit - MBS2885344 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.25-16 ng/mL

Search more