USP10

Gene Symbol	USP10
Entrez Gene	9100
Alt Symbol	UBPO
Species	Human
Gene Type	protein-coding
Description	ubiquitin specific peptidase 10
Other Description	deubiquitinating enzyme 10|ubiquitin carboxyl-terminal hydrolase 10|ubiquitin specific protease 10|ubiquitin thioesterase 10|ubiquitin thiolesterase 10|ubiquitin-specific-processing protease 10
Swissprots	Q9BWG7 Q14694 B2RDJ8 B4DS84 Q9NSL7
Accessions	CBX53857 EAW95470 EAW95471 Q14694 AK055375 AK293304 BAG56825 AK299618 BAG61546 AK315570 BAG37945 AL162049 CAB82392 BC000263 AAH00263 BC064516 AAH64516 BX537402 CAD97644 CR749515 CAH18330 D80012 BAA11507 DB077919 DQ892553 ABM83479 DQ895764 ABM86690 GD151792 XM_006721330 XP_006721393 XM_006721331 XP_006721394 XM_006721332 XP_006721395 XM_011523440 XP_011521742 XM_011523441 XP_011521743 XM_011523442 XP_011521744 XM_011523443 XP_011521745 NM_001272075 NP_001259004 NM_005153 NP_005144 NR_073577 NR_073578
Function	Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34- containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. {ECO:0000269|PubMed:11439350, ECO:00
Subcellular Location	Cytoplasm. Nucleus. Early endosome. Note=Cytoplasmic in normal conditions. After DNA damage, translocates to the nucleus following phosphorylation by ATM.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:11439350}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human USP10 full length protein - ab198669 from Abcam Category Protein Prices $1,187.00 Sizes 50 µg Source Baculovirus infected sf9 cells Species Human

Human USP10 protein fragment - ab152951 from Abcam Category Protein Source Wheat germ Species Human

USP10 Antibody Blocking Peptide - LS-E4819 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP10 Antibody Blocking Peptide - LS-E30944 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

USP10 Antibody Blocking Peptide - LS-E21695 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP10 Antibody Blocking Peptide - LS-E21696 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP10 Partial Recombinant Protein - H00009100-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

USP10 Recombinant Protein - H00009100-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

USP10 Peptide - NBP1-77170PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

USP10-Antibody-Center-Blocking-Peptide - BP17199c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

USP32 blocking peptide - GTX88693-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

Usp10 Blocking Peptide - 33R-7850 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

USP10 - H00009100-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

USP10 - H00009100-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

USP10 - H00009100-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

USP10 - H00009100-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

USP10 control peptide - AP26230CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

USP10 Peptide - 5803P from ProSci Category Peptide Species Human

USP10 fusion protein - Ag7106 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

USP10 fusion protein - ag7233 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

USP10 Active Human Recombinant Protein - GWB-D66F05 from Genway Biotech Category Protein Prices $566.00 Sizes 50 µg Species Human

Recombinant Human USP10, Flag-tagged - USP10-391H from Creative Biomart Category Protein Source Baculovirus

Recombinant Human USP10, GST-tagged - USP10-3615H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human USP10, His-SUMO-tagged - USP10-146H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Ubiquitin carboxyl-terminal hydrolase 10(USP10) - CSB-YP613516HU CSB-EP613516HU CSB-BP613516HU CSB-MP613516HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

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