| Gene Symbol | USP10 |
|---|---|
| Entrez Gene | 9100 |
| Alt Symbol | UBPO |
| Species | Human |
| Gene Type | protein-coding |
| Description | ubiquitin specific peptidase 10 |
| Other Description | deubiquitinating enzyme 10|ubiquitin carboxyl-terminal hydrolase 10|ubiquitin specific protease 10|ubiquitin thioesterase 10|ubiquitin thiolesterase 10|ubiquitin-specific-processing protease 10 |
| Swissprots | Q9BWG7 Q14694 B2RDJ8 B4DS84 Q9NSL7 |
| Accessions | CBX53857 EAW95470 EAW95471 Q14694 AK055375 AK293304 BAG56825 AK299618 BAG61546 AK315570 BAG37945 AL162049 CAB82392 BC000263 AAH00263 BC064516 AAH64516 BX537402 CAD97644 CR749515 CAH18330 D80012 BAA11507 DB077919 DQ892553 ABM83479 DQ895764 ABM86690 GD151792 XM_006721330 XP_006721393 XM_006721331 XP_006721394 XM_006721332 XP_006721395 XM_011523440 XP_011521742 XM_011523441 XP_011521743 XM_011523442 XP_011521744 XM_011523443 XP_011521745 NM_001272075 NP_001259004 NM_005153 NP_005144 NR_073577 NR_073578 |
| Function | Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34- containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. {ECO:0000269|PubMed:11439350, ECO:00 |
| Subcellular Location | Cytoplasm. Nucleus. Early endosome. Note=Cytoplasmic in normal conditions. After DNA damage, translocates to the nucleus following phosphorylation by ATM. |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:11439350}. |
Ubiquitin carboxyl-terminal hydrolase 10 (USP10), Human, ELISA Kit - E01U0055 from ARP American Research Products
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USP10 (Human) IP-WB Antibody Pair - H00009100-PW1 from Acris Antibodies
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Ubiquitin carboxyl terminal hydrolase 10 (USP10), ELISA Kit - MBS7228023 from MyBioSource
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Ubiquitin carboxyl-terminal hydrolase 10 (USP10), ELISA Kit - MBS7204889 from MyBioSource
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Ubiquitin carboxyl-terminal hydrolase 10 (USP10), ELISA Kit - MBS7253545 from MyBioSource
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Ubiquitin carboxyl-terminal hydrolase 10 (USP10), ELISA Kit - MBS7208768 from MyBioSource
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Ubiquitin carboxyl-terminal hydrolase 10 (USP10), ELISA Kit - MBS7229526 from MyBioSource
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Ubiquitin carboxyl-terminal hydrolase 10 (USP10), ELISA Kit - MBS7248989 from MyBioSource
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Ubiquitin carboxyl-terminal hydrolase 10 (USP10), ELISA Kit - MBS7230102 from MyBioSource
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Ubiquitin carboxyl-terminal hydrolase 10 (USP10), ELISA Kit - MBS7207335 from MyBioSource
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Ubiquitin carboxyl-terminal hydrolase 10 (USP10), ELISA Kit - MBS7238847 from MyBioSource
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Ubiquitin carboxyl-terminal hydrolase 10 (USP10), ELISA Kit - MBS7219957 from MyBioSource
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ubiquitin specific peptidase 10, ELISA Kit - MBS9325938 from MyBioSource
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ubiquitin specific peptidase 10, ELISA Kit - MBS9341627 from MyBioSource
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Human USP10 ELISA Kit - E040258 from Biobool
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