| Gene Symbol |
USP10
|
| Entrez Gene |
9100
|
| Alt Symbol |
UBPO
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin specific peptidase 10
|
| Other Description |
deubiquitinating enzyme 10|ubiquitin carboxyl-terminal hydrolase 10|ubiquitin specific protease 10|ubiquitin thioesterase 10|ubiquitin thiolesterase 10|ubiquitin-specific-processing protease 10
|
| Swissprots |
Q9BWG7 Q14694 B2RDJ8 B4DS84 Q9NSL7
|
| Accessions |
CBX53857 EAW95470 EAW95471 Q14694 AK055375 AK293304 BAG56825 AK299618 BAG61546 AK315570 BAG37945 AL162049 CAB82392 BC000263 AAH00263 BC064516 AAH64516 BX537402 CAD97644 CR749515 CAH18330 D80012 BAA11507 DB077919 DQ892553 ABM83479 DQ895764 ABM86690 GD151792 XM_006721330 XP_006721393 XM_006721331 XP_006721394 XM_006721332 XP_006721395 XM_011523440 XP_011521742 XM_011523441 XP_011521743 XM_011523442 XP_011521744 XM_011523443 XP_011521745 NM_001272075 NP_001259004 NM_005153 NP_005144 NR_073577 NR_073578
|
| Function |
Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34- containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. {ECO:0000269|PubMed:11439350, ECO:00
|
| Subcellular Location |
Cytoplasm. Nucleus. Early endosome. Note=Cytoplasmic in normal conditions. After DNA damage, translocates to the nucleus following phosphorylation by ATM.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:11439350}.
|