Gene Symbol | SELK |
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Entrez Gene | 58515 |
Alt Symbol | HSPC030, HSPC297, SelK |
Species | Human |
Gene Type | protein-coding |
Description | selenoprotein K |
Other Description | - |
Swissprots | Q8IZQ3 Q9P085 Q9Y6D0 |
Accessions | EAW65301 Q9Y6D0 AF085359 AAD40194 AF161415 AAF28975 AF537132 AAN61473 AK123406 AK289594 BAF82283 BC013162 AAH13162 BM762385 NM_021237 NP_067060 |
Function | Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration. Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins. Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation. Plays a role in protection of cells from ER stress- induced apoptosis. Protects cells from oxidative stress when overexpressed in cardiomyocytes. {ECO:0000269|PubMed:16962588, ECO:0000269|PubMed:20692228, ECO:0000269|PubMed:22016385}. |
Subcellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein. |
Tissue Specificity | Highly expressed in heart. {ECO:0000269|PubMed:16962588}. |
Selenoprotein K (H-48) - sc-98773 from Santa Cruz Biotechnology
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Anti-SELK antibody - ab121276 from Abcam
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Anti-SELK antibody - C-terminal - ab139949 from Abcam
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Anti-SELK / Selenoprotein K Antibody (aa32-61) - LS-C168944 from LifeSpan Bioscience
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Anti-SELK / Selenoprotein K Antibody (C-Terminus) - LS-C153629 from LifeSpan Bioscience
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Anti-SELK / Selenoprotein K Antibody (aa31-61, AP) - LS-C240529 from LifeSpan Bioscience
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Anti-SELK / Selenoprotein K Antibody (aa31-61, Biotin) - LS-C240531 from LifeSpan Bioscience
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Anti-SELK / Selenoprotein K Antibody (aa31-61, FITC) - LS-C240532 from LifeSpan Bioscience
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Anti-SELK / Selenoprotein K Antibody (aa31-61, APC) - LS-C240533 from LifeSpan Bioscience
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Anti-SELK / Selenoprotein K Antibody (aa31-61, PE) - LS-C240535 from LifeSpan Bioscience
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Anti-SELK / Selenoprotein K Antibody (aa31-61, Azide-free, HRP) - LS-C248107 from LifeSpan Bioscience
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Anti-SELK / Selenoprotein K Antibody (aa31-61) - LS-C330101 from LifeSpan Bioscience
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SELK Antibody - NBP1-86120 from Novus Biologicals
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Anti-SELK antibody produced in rabbit - HPA008196 from Sigma-Aldrich
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ANTI-SELK (CENTER) antibody produced in rabbit - SAB1304474 from Sigma-Aldrich
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Anti-SELK antibody produced in rabbit - SAB3500810 from Sigma-Aldrich
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SELK-Antibody-Center - AP13595c from Abgent, a WuXi AppTec company
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SELK Antibody - middle region (OAAB09896) - OAAB09896 from Aviva Systems Biology
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SELK antibody - orb75825 from Biorbyt
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SELK Antibody - abx027489 from Abbexa
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Selenoprotein K (SELK) antibody - 12561-1-AP from Acris Antibodies
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Selenoprotein K (SELK) (C-term) antibody - AP55499PU-N from Acris Antibodies
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Selenoprotein K (SELK) antibody - H00058515-A01 from Acris Antibodies
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Rabbit Anti-SELK (Center) - 102-12069 from RayBiotech
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SELK Antibody - 6975 from ProSci
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