| Gene Symbol |
SELK
|
| Entrez Gene |
58515
|
| Alt Symbol |
HSPC030, HSPC297, SelK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
selenoprotein K
|
| Other Description |
-
|
| Swissprots |
Q8IZQ3 Q9P085 Q9Y6D0
|
| Accessions |
EAW65301 Q9Y6D0 AF085359 AAD40194 AF161415 AAF28975 AF537132 AAN61473 AK123406 AK289594 BAF82283 BC013162 AAH13162 BM762385 NM_021237 NP_067060
|
| Function |
Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration. Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins. Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation. Plays a role in protection of cells from ER stress- induced apoptosis. Protects cells from oxidative stress when overexpressed in cardiomyocytes. {ECO:0000269|PubMed:16962588, ECO:0000269|PubMed:20692228, ECO:0000269|PubMed:22016385}.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein.
|
| Tissue Specificity |
Highly expressed in heart. {ECO:0000269|PubMed:16962588}.
|