THEM4

Gene Symbol THEM4
Entrez Gene 117145
Alt Symbol CTMP
Species Human
Gene Type protein-coding
Description thioesterase superfamily member 4
Other Description C-terminal modulator protein|acyl-CoA thioesterase THEM4|acyl-coenzyme A thioesterase THEM4|carboxyl-terminal modulator protein
Swissprots Q96KR2 B2RBX2 Q5T1C6
Accessions EAW53400 EAW53401 EAW53402 Q5T1C6 AF075119 AJ313515 CAC86384 AK024219 AK096211 AK130716 BAC85412 AK289494 BAF82183 AK314852 BAG37369 BC017339 BC065277 AAH65277 BE349541 BM688785 BM787449 BQ774123 DC353229 DQ579333 DQ586175 XM_011509142 XP_011507444 NM_053055 NP_444283 NM_176853
Function Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays an role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane. {ECO:0000269|PubMed:11598301, ECO:0000269|PubMed:17615157, ECO:0000269|PubMed:19168129, ECO:0000269|PubMed:19421406, ECO:0000269|PubMed:19453107, ECO:0000269|PubMed:22871024}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:11598301}. Cell projection, ruffle membrane {ECO:0000269|PubMed:11598301}. Cytoplasm {ECO:0000269|PubMed:19604401}. Mitochondrion {ECO:0000269|PubMed:19168129, ECO:0000269|PubMed:19421406, ECO:0000269|PubMed:19604401}. Mitochondrion inner membrane; Peripheral membrane protein {ECO:0000269|PubMed:19168129}. Mitochondrion intermembrane space {ECO:0000269|PubMed:19168129, ECO:0000269|PubMed:19604401}. Note=Released from the mitochondria into the cytosol in response to apoptotic stimuli. {ECO:0000269|PubMed:19168129}.
Tissue Specificity Expressed predominantly in skeletal muscle, testis, uterus, brain and kidney. Down-regulated in glioblastoma or glioma compared to non-neoplastic brain due to promoter hypermethylation. {ECO:0000269|PubMed:11598301, ECO:0000269|PubMed:15026474}.
Top Pathways PI3K-Akt signaling pathway

CTMP CRISPR/Cas9 KO Plasmid (h) - sc-410265 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CTMP HDR Plasmid (h) - sc-410265-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CTMP Double Nickase Plasmid (h) - sc-410265-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CTMP Double Nickase Plasmid (h2) - sc-410265-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CTMP CRISPR Activation Plasmid (h) - sc-410265-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CTMP CRISPR Activation Plasmid (h2) - sc-410265-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CTMP Lentiviral Activation Particles (h) - sc-410265-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CTMP Lentiviral Activation Particles (h2) - sc-410265-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CTMP siRNA (h) - sc-60469 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CTMP shRNA Plasmid (h) - sc-60469-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CTMP shRNA (h) Lentiviral Particles - sc-60469-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU071241 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21308 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21308 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

THEM4 siRNA (Human) - CRJ4549 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

THEM4 - MBS8228133 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human THEM4 (NM_053055.4) - SHH426840 from Creative biogene

Category siRNA
Species Reactivities Human

Human THEM4 siRNA - orb275050 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

THEM4 shRNA Plasmid (Human) - CHJ4549 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

THEM4 miRNA 3'UTR clone - MiUTR3H-08415 from Creative biogene

Species Reactivities Human
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