THEM4

Gene Symbol THEM4
Entrez Gene 117145
Alt Symbol CTMP
Species Human
Gene Type protein-coding
Description thioesterase superfamily member 4
Other Description C-terminal modulator protein|acyl-CoA thioesterase THEM4|acyl-coenzyme A thioesterase THEM4|carboxyl-terminal modulator protein
Swissprots Q96KR2 B2RBX2 Q5T1C6
Accessions EAW53400 EAW53401 EAW53402 Q5T1C6 AF075119 AJ313515 CAC86384 AK024219 AK096211 AK130716 BAC85412 AK289494 BAF82183 AK314852 BAG37369 BC017339 BC065277 AAH65277 BE349541 BM688785 BM787449 BQ774123 DC353229 DQ579333 DQ586175 XM_011509142 XP_011507444 NM_053055 NP_444283 NM_176853
Function Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays an role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane. {ECO:0000269|PubMed:11598301, ECO:0000269|PubMed:17615157, ECO:0000269|PubMed:19168129, ECO:0000269|PubMed:19421406, ECO:0000269|PubMed:19453107, ECO:0000269|PubMed:22871024}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:11598301}. Cell projection, ruffle membrane {ECO:0000269|PubMed:11598301}. Cytoplasm {ECO:0000269|PubMed:19604401}. Mitochondrion {ECO:0000269|PubMed:19168129, ECO:0000269|PubMed:19421406, ECO:0000269|PubMed:19604401}. Mitochondrion inner membrane; Peripheral membrane protein {ECO:0000269|PubMed:19168129}. Mitochondrion intermembrane space {ECO:0000269|PubMed:19168129, ECO:0000269|PubMed:19604401}. Note=Released from the mitochondria into the cytosol in response to apoptotic stimuli. {ECO:0000269|PubMed:19168129}.
Tissue Specificity Expressed predominantly in skeletal muscle, testis, uterus, brain and kidney. Down-regulated in glioblastoma or glioma compared to non-neoplastic brain due to promoter hypermethylation. {ECO:0000269|PubMed:11598301, ECO:0000269|PubMed:15026474}.
Top Pathways PI3K-Akt signaling pathway

THEM4 293T Cell Transient Overexpression Lysate(Denatured) - H00117145-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

THEM4 Overexpression Lysate (Denatured) - H00117145-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
THEM4 transfected lysate.

THEM4 Overexpression Lysate (Native) - NBP2-04410 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: THEM4 Overexpression Lysate (Adult Normal) [NBP2-04410] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for THEM4.

Panoply™ Human THEM4 Knockdown Stable Cell Line - CSC-DC015905 from Creative biogene

Category Cell Line
Species Human
Search more