| Gene Symbol |
THEM4
|
| Entrez Gene |
117145
|
| Alt Symbol |
CTMP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
thioesterase superfamily member 4
|
| Other Description |
C-terminal modulator protein|acyl-CoA thioesterase THEM4|acyl-coenzyme A thioesterase THEM4|carboxyl-terminal modulator protein
|
| Swissprots |
Q96KR2 B2RBX2 Q5T1C6
|
| Accessions |
EAW53400 EAW53401 EAW53402 Q5T1C6 AF075119 AJ313515 CAC86384 AK024219 AK096211 AK130716 BAC85412 AK289494 BAF82183 AK314852 BAG37369 BC017339 BC065277 AAH65277 BE349541 BM688785 BM787449 BQ774123 DC353229 DQ579333 DQ586175 XM_011509142 XP_011507444 NM_053055 NP_444283 NM_176853
|
| Function |
Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays an role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane. {ECO:0000269|PubMed:11598301, ECO:0000269|PubMed:17615157, ECO:0000269|PubMed:19168129, ECO:0000269|PubMed:19421406, ECO:0000269|PubMed:19453107, ECO:0000269|PubMed:22871024}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:11598301}. Cell projection, ruffle membrane {ECO:0000269|PubMed:11598301}. Cytoplasm {ECO:0000269|PubMed:19604401}. Mitochondrion {ECO:0000269|PubMed:19168129, ECO:0000269|PubMed:19421406, ECO:0000269|PubMed:19604401}. Mitochondrion inner membrane; Peripheral membrane protein {ECO:0000269|PubMed:19168129}. Mitochondrion intermembrane space {ECO:0000269|PubMed:19168129, ECO:0000269|PubMed:19604401}. Note=Released from the mitochondria into the cytosol in response to apoptotic stimuli. {ECO:0000269|PubMed:19168129}.
|
| Tissue Specificity |
Expressed predominantly in skeletal muscle, testis, uterus, brain and kidney. Down-regulated in glioblastoma or glioma compared to non-neoplastic brain due to promoter hypermethylation. {ECO:0000269|PubMed:11598301, ECO:0000269|PubMed:15026474}.
|
| Top Pathways |
PI3K-Akt signaling pathway
|