THEM4

Gene Symbol THEM4
Entrez Gene 117145
Alt Symbol CTMP
Species Human
Gene Type protein-coding
Description thioesterase superfamily member 4
Other Description C-terminal modulator protein|acyl-CoA thioesterase THEM4|acyl-coenzyme A thioesterase THEM4|carboxyl-terminal modulator protein
Swissprots Q96KR2 B2RBX2 Q5T1C6
Accessions EAW53400 EAW53401 EAW53402 Q5T1C6 AF075119 AJ313515 CAC86384 AK024219 AK096211 AK130716 BAC85412 AK289494 BAF82183 AK314852 BAG37369 BC017339 BC065277 AAH65277 BE349541 BM688785 BM787449 BQ774123 DC353229 DQ579333 DQ586175 XM_011509142 XP_011507444 NM_053055 NP_444283 NM_176853
Function Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays an role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane. {ECO:0000269|PubMed:11598301, ECO:0000269|PubMed:17615157, ECO:0000269|PubMed:19168129, ECO:0000269|PubMed:19421406, ECO:0000269|PubMed:19453107, ECO:0000269|PubMed:22871024}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:11598301}. Cell projection, ruffle membrane {ECO:0000269|PubMed:11598301}. Cytoplasm {ECO:0000269|PubMed:19604401}. Mitochondrion {ECO:0000269|PubMed:19168129, ECO:0000269|PubMed:19421406, ECO:0000269|PubMed:19604401}. Mitochondrion inner membrane; Peripheral membrane protein {ECO:0000269|PubMed:19168129}. Mitochondrion intermembrane space {ECO:0000269|PubMed:19168129, ECO:0000269|PubMed:19604401}. Note=Released from the mitochondria into the cytosol in response to apoptotic stimuli. {ECO:0000269|PubMed:19168129}.
Tissue Specificity Expressed predominantly in skeletal muscle, testis, uterus, brain and kidney. Down-regulated in glioblastoma or glioma compared to non-neoplastic brain due to promoter hypermethylation. {ECO:0000269|PubMed:11598301, ECO:0000269|PubMed:15026474}.
Top Pathways PI3K-Akt signaling pathway

Human THEM4 full length protein - ab165122 from Abcam

Category Protein
Source Wheat germ
Species Human
ab165122 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Human THEM4 protein fragment - ab165123 from Abcam

Category Protein
Source Wheat germ
Species Human
ab165123 on a 12.5% SDS-PAGE stained with Coomassie Blue.

CTMP / THEM4 Antibody Blocking Peptide - LS-E30724 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 50 µg

Recombinant Human THEM4 Protein - H00117145-P01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

Recombinant Human THEM4 Protein - H00117145-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

THEM4 Blocking Peptide - NBP1-77360PEP from Novus Biologicals

Category Peptide
Prices $129.00
Sizes 50 µg
Species Human

THEM4 / CTMP - H00117145-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

THEM4 / CTMP - H00117145-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

THEM4 / CTMP - H00117145-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

THEM4 / CTMP - H00117145-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

THEM4 / CTMP Control Peptide - AP30876CP-N from Acris Antibodies

Category Peptide
Prices $135.00
Sizes 50 µg

THEM4 Peptide - 5227P from ProSci

Category Peptide
Species Human

THEM4 fusion protein - ag6296 from Proteintech Group

Category Protein
Source E. coli-derived, PET28a
Species Human

THEM4 fusion protein - Ag6244 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PGEX-4T
Species Human

Recombinant Human Thioesterase superfamily member 4(THEM4) - CSB-YP023494HU CSB-EP023494HU CSB-BP023494HU CSB-MP023494HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

Thioesterase superfamily member 4 (THEM4) - TP309396 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
Thioesterase superfamily member 4 (THEM4)

Thioesterase superfamily member 4 (THEM4), Recombinant Protein - MBS1461339 from MyBioSource

Category Protein
Prices $955.00, $955.00, $1,175.00, $1,175.00, $1,425.00, $1,425.00, $1,890.00, $1,890.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

THEM4 Recombinant Protein Antigen - NBP1-84336PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

THEM4 Peptide, Human - M34GP15905H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human
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