THEM4

Gene Symbol THEM4
Entrez Gene 117145
Alt Symbol CTMP
Species Human
Gene Type protein-coding
Description thioesterase superfamily member 4
Other Description C-terminal modulator protein|acyl-CoA thioesterase THEM4|acyl-coenzyme A thioesterase THEM4|carboxyl-terminal modulator protein
Swissprots Q96KR2 B2RBX2 Q5T1C6
Accessions EAW53400 EAW53401 EAW53402 Q5T1C6 AF075119 AJ313515 CAC86384 AK024219 AK096211 AK130716 BAC85412 AK289494 BAF82183 AK314852 BAG37369 BC017339 BC065277 AAH65277 BE349541 BM688785 BM787449 BQ774123 DC353229 DQ579333 DQ586175 XM_011509142 XP_011507444 NM_053055 NP_444283 NM_176853
Function Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays an role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane. {ECO:0000269|PubMed:11598301, ECO:0000269|PubMed:17615157, ECO:0000269|PubMed:19168129, ECO:0000269|PubMed:19421406, ECO:0000269|PubMed:19453107, ECO:0000269|PubMed:22871024}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:11598301}. Cell projection, ruffle membrane {ECO:0000269|PubMed:11598301}. Cytoplasm {ECO:0000269|PubMed:19604401}. Mitochondrion {ECO:0000269|PubMed:19168129, ECO:0000269|PubMed:19421406, ECO:0000269|PubMed:19604401}. Mitochondrion inner membrane; Peripheral membrane protein {ECO:0000269|PubMed:19168129}. Mitochondrion intermembrane space {ECO:0000269|PubMed:19168129, ECO:0000269|PubMed:19604401}. Note=Released from the mitochondria into the cytosol in response to apoptotic stimuli. {ECO:0000269|PubMed:19168129}.
Tissue Specificity Expressed predominantly in skeletal muscle, testis, uterus, brain and kidney. Down-regulated in glioblastoma or glioma compared to non-neoplastic brain due to promoter hypermethylation. {ECO:0000269|PubMed:11598301, ECO:0000269|PubMed:15026474}.
Top Pathways PI3K-Akt signaling pathway

CTMP Antibody - 4612 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa, NIH/3T3 and C6 cells, using the CTMP Antibody.

CTMP (H-10) - sc-390353 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CTMP (H-10): sc-390353. Western blot analysis of CTMP expression in human skeletal muscle tissue extract.

CTMP (C-18) - sc-47857 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CTMP (N-15) - sc-47860 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CTMP (N-15): sc-47860. Western blot analysis of CTMP expression in non-transfected: sc-117752 (A) and human CTMP transfected: sc-117060 (B) 293T whole cell lysates.

CTMP (K-14) - sc-47858 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CTMP (K-14): sc-47858. Western blot analysis of CTMP expression in non-transfected: sc-117752 (A) and human CTMP transfected: sc-117060 (B) 293T whole cell lysates.

CTMP (H-137) - sc-292870 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-THEM4 antibody - ab106435 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of THEM4 in Human liver tissue with ab106435 at 20 ug/mL.

Anti-THEM4 antibody - ab113713 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab113713, at 5 µg/ml, staining THEM4 in formalin fixed, paraffin embedded Human kidney tissue by Immunohistochemistry.

Anti-THEM4 antibody - ab168500 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-THEM4 antibody (ab168500) at 1 µg/mlLane 1 : THEM4 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-CTMP / THEM4 Antibody - LS-C12396 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTMP / THEM4 Antibody (Internal) IHC-plus™ - LS-B5009 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Anti-THEM4 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5009 concentration 5 ug/ml.

THEM4 Antibody - NBP1-77360 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

THEM4 Antibody - NBP1-84336 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

THEM4 Antibody - NBP1-72118 from Novus Biologicals

Prices $399.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: THEM4 Antibody [NBP1-72118] - Staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

THEM4 Antibody - H00117145-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-THEM4 antibody produced in mouse - SAB1401968 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Polyclonal Anti-THEM4, antibody produced in mouse, purified immunoglobulin: <B>Cat. No. SAB1401968</B>: Antibody concentration: 0.1 - 5.0 μg/mL. Specific band of ~26.4 kDa using THEM4 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-THEM4 antibody produced in rabbit - HPA028161 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-THEM4: <B>Cat. No. HPA028161</B>: Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells.

CTMP antibody [N1C3] - GTX106880 from GeneTex

Host Rabbit
Clonality Polyclonal

THEM4 antibody - orb75222 from Biorbyt

Prices $723.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Western blot analysis of human liver tissue lysate at (A) 1 and (B) 2 ug/mL using THEM4 antibody

THEM4 Polyclonal Antibody - A5124 from ABclonal

Prices $200.00, $480.00
Sizes 50 µg, 200 µg
Host Rabbit
Clonality Polyclonal

CTMP antibody - orb94288 from Biorbyt

Prices $536.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal
Immunohistochemical staining of paraffin embedded human kidney tissue using CTMP antibody (primary antibody at 1:200)

THEM4 Antibody - abx003922 from Abbexa

Host Rabbit
Clonality Polyclonal

THEM4 / CTMP antibody - 14692-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded Endometrial cancer using 14692-1-AP(THEM4 Antibody) at Dilution 1:50 (under 10x lens)

THEM4 / CTMP antibody - AP23880PU-N from Acris Antibodies

Prices $430.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

THEM4 / CTMP antibody - AP30876PU-N from Acris Antibodies

Prices $340.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of THEM4 in human liver tissue with AP30876PU-N at 2.5 μg/ml.
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