Gene Symbol | TBPL1 |
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Entrez Gene | 9519 |
Alt Symbol | MGC:8389, MGC:9620, STUD, TLF, TLP, TRF2 |
Species | Human |
Gene Type | protein-coding |
Description | TBP-like 1 |
Other Description | 21-kDA TBP-like protein|TATA box-binding protein-like protein 1|TATA box-binding protein-related factor 2|TBP-related factor 2|TBP-related protein|second TBP of unique DNA protein |
Swissprots | Q9BWD5 A8K8F5 P62380 |
Accessions | EAW47995 EAW47996 EAW47997 EAW47998 P62380 AB020881 BAA75218 AF130312 AAD24800 AF136570 AAD28785 AI187713 AK292320 BAF85009 AK313645 BAG36402 BC000381 AAH00381 BC017559 AAH17559 BI560657 BI828497 EU446932 ABZ92461 R42082 NM_001253676 NP_001240605 NM_004865 NP_004856 |
Function | Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box. {ECO:0000269|PubMed:10082669, ECO:0000269|PubMed:10220372, ECO:0000269|PubMed:15767669, ECO:0000269|PubMed:24958592}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
Tissue Specificity | Ubiquitously expressed, with highest levels in the testis and ovary. {ECO:0000269|PubMed:10082669, ECO:0000269|PubMed:17570761}. |
Top Pathways | Huntington's disease, HTLV-I infection, Herpes simplex infection, Viral carcinogenesis, Epstein-Barr virus infection |
TLF CRISPR/Cas9 KO Plasmid (h) - sc-405953 from Santa Cruz Biotechnology
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TLF HDR Plasmid (h) - sc-405953-HDR from Santa Cruz Biotechnology
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TLF Double Nickase Plasmid (h) - sc-405953-NIC from Santa Cruz Biotechnology
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TLF Double Nickase Plasmid (h2) - sc-405953-NIC-2 from Santa Cruz Biotechnology
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TLF CRISPR Activation Plasmid (h) - sc-405953-ACT from Santa Cruz Biotechnology
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TLF CRISPR Activation Plasmid (h2) - sc-405953-ACT-2 from Santa Cruz Biotechnology
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TLF Lentiviral Activation Particles (h) - sc-405953-LAC from Santa Cruz Biotechnology
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TLF Lentiviral Activation Particles (h2) - sc-405953-LAC-2 from Santa Cruz Biotechnology
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TLF siRNA (h) - sc-44158 from Santa Cruz Biotechnology
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TLF shRNA Plasmid (h) - sc-44158-SH from Santa Cruz Biotechnology
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TLF shRNA (h) Lentiviral Particles - sc-44158-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU054161 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21098 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21098 from Sigma-Aldrich
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TBPL1 siRNA (Human) - CRH6325 from Cohesion Biosciences
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TBP like protein TLP RNAi - H00009519-R01 from Novus Biologicals
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TBPL1 - MBS8237828 from MyBioSource
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shRNA set against Human TBPL1 (NM_004865.3) - SHH424276 from Creative biogene
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TBPL1 shRNA Plasmid (Human) - CHH6325 from Cohesion Biosciences
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TBPL1 miRNA 3'UTR clone - MiUTR3H-07760 from Creative biogene
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