| Gene Symbol |
TBPL1
|
| Entrez Gene |
9519
|
| Alt Symbol |
MGC:8389, MGC:9620, STUD, TLF, TLP, TRF2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TBP-like 1
|
| Other Description |
21-kDA TBP-like protein|TATA box-binding protein-like protein 1|TATA box-binding protein-related factor 2|TBP-related factor 2|TBP-related protein|second TBP of unique DNA protein
|
| Swissprots |
Q9BWD5 A8K8F5 P62380
|
| Accessions |
EAW47995 EAW47996 EAW47997 EAW47998 P62380 AB020881 BAA75218 AF130312 AAD24800 AF136570 AAD28785 AI187713 AK292320 BAF85009 AK313645 BAG36402 BC000381 AAH00381 BC017559 AAH17559 BI560657 BI828497 EU446932 ABZ92461 R42082 NM_001253676 NP_001240605 NM_004865 NP_004856
|
| Function |
Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box. {ECO:0000269|PubMed:10082669, ECO:0000269|PubMed:10220372, ECO:0000269|PubMed:15767669, ECO:0000269|PubMed:24958592}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitously expressed, with highest levels in the testis and ovary. {ECO:0000269|PubMed:10082669, ECO:0000269|PubMed:17570761}.
|
| Top Pathways |
Huntington's disease, HTLV-I infection, Herpes simplex infection, Viral carcinogenesis, Epstein-Barr virus infection
|
![Western Blot: TBP like protein TLP Overexpression Lysate (Adult Normal) [NBL1-16742] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TBP like protein TLP.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/11638_TBP%2520like%2520protein%2520TLP%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-16742-img0002.jpg)