Gene Symbol | TBPL1 |
---|---|
Entrez Gene | 9519 |
Alt Symbol | MGC:8389, MGC:9620, STUD, TLF, TLP, TRF2 |
Species | Human |
Gene Type | protein-coding |
Description | TBP-like 1 |
Other Description | 21-kDA TBP-like protein|TATA box-binding protein-like protein 1|TATA box-binding protein-related factor 2|TBP-related factor 2|TBP-related protein|second TBP of unique DNA protein |
Swissprots | Q9BWD5 A8K8F5 P62380 |
Accessions | EAW47995 EAW47996 EAW47997 EAW47998 P62380 AB020881 BAA75218 AF130312 AAD24800 AF136570 AAD28785 AI187713 AK292320 BAF85009 AK313645 BAG36402 BC000381 AAH00381 BC017559 AAH17559 BI560657 BI828497 EU446932 ABZ92461 R42082 NM_001253676 NP_001240605 NM_004865 NP_004856 |
Function | Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box. {ECO:0000269|PubMed:10082669, ECO:0000269|PubMed:10220372, ECO:0000269|PubMed:15767669, ECO:0000269|PubMed:24958592}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
Tissue Specificity | Ubiquitously expressed, with highest levels in the testis and ovary. {ECO:0000269|PubMed:10082669, ECO:0000269|PubMed:17570761}. |
Top Pathways | Huntington's disease, HTLV-I infection, Herpes simplex infection, Viral carcinogenesis, Epstein-Barr virus infection |