Gene Symbol | JDP2 |
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Entrez Gene | 122953 |
Alt Symbol | JUNDM2 |
Species | Human |
Gene Type | protein-coding |
Description | Jun dimerization protein 2 |
Other Description | jun dimerization protein 2|progesterone receptor co-activator |
Swissprots | O95430 Q9UIE4 J3KN58 Q8WYK2 |
Accessions | AAC98313 AAF21148 EAW81231 EAW81232 EAW81233 Q8WYK2 AB077880 BAB83896 AI916777 BC051303 AAH51303 BC068196 BE389064 BU740697 XM_005267332 XP_005267389 XM_006720032 XP_006720095 XM_011536431 XP_011534733 NM_001135047 NP_001128519 NM_001135048 NP_001128520 NM_001135049 NP_001128521 NM_130469 NP_569736 |
Function | Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin. {ECO:0000269|PubMed:12707301, ECO:0000269|PubMed:12903123, ECO:0000269|PubMed:16026868, ECO:0000269|PubMed:16518400}. |
Subcellular Location | Nucleus {ECO:0000305}. |
JDP2 CRISPR/Cas9 KO Plasmid (h) - sc-406888 from Santa Cruz Biotechnology
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JDP2 HDR Plasmid (h) - sc-406888-HDR from Santa Cruz Biotechnology
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JDP2 Double Nickase Plasmid (h) - sc-406888-NIC from Santa Cruz Biotechnology
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JDP2 Double Nickase Plasmid (h2) - sc-406888-NIC-2 from Santa Cruz Biotechnology
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JDP2 CRISPR Activation Plasmid (h) - sc-406888-ACT from Santa Cruz Biotechnology
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JDP2 CRISPR Activation Plasmid (h2) - sc-406888-ACT-2 from Santa Cruz Biotechnology
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JDP2 Lentiviral Activation Particles (h) - sc-406888-LAC from Santa Cruz Biotechnology
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JDP2 Lentiviral Activation Particles (h2) - sc-406888-LAC-2 from Santa Cruz Biotechnology
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JDP2 siRNA (h) - sc-38017 from Santa Cruz Biotechnology
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JDP2 shRNA Plasmid (h) - sc-38017-SH from Santa Cruz Biotechnology
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JDP2 shRNA (h) Lentiviral Particles - sc-38017-V from Santa Cruz Biotechnology
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JDP2 RNAi - H00122953-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN10863 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10863 from Sigma-Aldrich
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JDP2 siRNA (Human) - CRJ4717 from Cohesion Biosciences
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JDP2, siRNA - MBS8237608 from MyBioSource
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JDP2 CRISPR/Cas9 KO Plasmid (h2) - sc-406888-KO-2 from Santa Cruz Biotechnology
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JDP2 HDR Plasmid (h2) - sc-406888-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human JDP2 (NM_130469.3) - SHH322031 from Creative biogene
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JDP2 shRNA Plasmid (Human) - CHJ4717 from Cohesion Biosciences
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JDP2 miRNA 3'UTR clone - MiUTR4H-TG11543 from Creative biogene
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