| Gene Symbol |
JDP2
|
| Entrez Gene |
122953
|
| Alt Symbol |
JUNDM2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Jun dimerization protein 2
|
| Other Description |
jun dimerization protein 2|progesterone receptor co-activator
|
| Swissprots |
O95430 Q9UIE4 J3KN58 Q8WYK2
|
| Accessions |
AAC98313 AAF21148 EAW81231 EAW81232 EAW81233 Q8WYK2 AB077880 BAB83896 AI916777 BC051303 AAH51303 BC068196 BE389064 BU740697 XM_005267332 XP_005267389 XM_006720032 XP_006720095 XM_011536431 XP_011534733 NM_001135047 NP_001128519 NM_001135048 NP_001128520 NM_001135049 NP_001128521 NM_130469 NP_569736
|
| Function |
Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin. {ECO:0000269|PubMed:12707301, ECO:0000269|PubMed:12903123, ECO:0000269|PubMed:16026868, ECO:0000269|PubMed:16518400}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
![Western Blot: JDP2 Overexpression Lysate (Adult Normal) [NBL1-12101] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for JDP2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5954_JDP2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12101-img0002.jpg)
![Western Blot: JDP2 Overexpression Lysate (Adult Normal) [NBP2-09560] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for JDP2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/24708_JDP2%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-09560-img0001.jpg)