Cdkn2a

Gene Symbol Cdkn2a
Entrez Gene 12578
Alt Symbol ARF-INK4a, Arf, INK4a-ARF, Ink4a/Arf, MTS1, Pctr1, p16, p16(INK4a), p16INK4a, p19<ARF>, p19ARF
Species Mouse
Gene Type protein-coding
Description cyclin-dependent kinase inhibitor 2A
Other Description CDK4I|cdkn2a|cyclin-dependent kinase 4 inhibitor A|cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4)|cyclin-dependent kinase inhibitor 2A, isoforms 1/2|cyclin-dependent kinase inhibitor protein|mitochondrial smARF|p16-INK4|p16-INK4a
Swissprots Q9QWH8 Q9QWH6 Q792X7 Q78E39 P97510 Q78E57 P51480 A2ANM1 Q9QXC7 O89088 Q6PEA2 P97937 Q4U255 A2ANM2 Q64364 Q9QWH7 Q9R051
Accessions AAB39600 AAB61416 AAC00051 AAC00052 AAC00053 AAC00054 AAC52987 AAD00223 AAD00224 AAD00225 AAD00226 AAD00227 AAD00228 AAD00229 AAD00230 AAD00231 AAD11438 AAD33245 AAK83159 CAB65598 CAI84565 EDL30951 P51480 Q64364 AB221638 AF044335 AAC08962 AF044336 AAC08963 AK155307 BAE33180 BC058190 AAH58190 EU071702 ABS85193 L76092 AAC42080 L76150 AAA85453 S80650 AAB35770 NM_001040654 NP_001035744 NM_009877 NP_034007
Function Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2- induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination (By similarit
Subcellular Location Nucleus, nucleolus {ECO:0000250|UniProtKB:Q8N726, ECO:0000269|PubMed:10359817, ECO:0000269|PubMed:15567177, ECO:0000269|PubMed:15601844, ECO:0000269|PubMed:8521522}. Nucleus, nucleoplasm {ECO:0000250}.
Top Pathways Cell cycle, Glioma, Pancreatic cancer, Non-small cell lung cancer, Bladder cancer

p19 ARF (5-C3-1) - sc-32748 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rat
Clonality Monoclonal
p19 ARF (5-C3-1): sc-32748. Immunofluorescence staining of wtMEFp6 cells showing nuclear localization. Kindly provided by St. Jude Children's Hospital.

p19 ARF (12-A1-1) - sc-32749 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rat
Clonality Monoclonal
p19 ARF (12-A1-1): sc-32749. Western blot analysis of mouse recombinant p19 ARF fusion protein.

p19 ARF (G-19) - sc-7403 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

p19 ARF (M-60) - sc-22784 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
p19 ARF (M-60): sc-22784. Western blot analysis of p19 ARF expression in C3H/10T1/2 (A), NIH/3T3 (B), 3T3-L1 (C), MH-S (D), AMJ2-C8 (E) and I-11.15 (F) whole cell lysates.

p19 ARF (M-20) - sc-7401 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

p19 (E-11) - sc-1665 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p19 (E-11): sc-1665. Western blot analysis of mouse recombinant p19 fusion protein.

Anti-CDKN2A/p19ARF antibody - ab80 from Abcam

Prices $400.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CDKN2A/p19ARF antibody (ab80) at 1 µg/mlLane 1 : 30 ug of mouse embryonic fibroblast total cell extract.Lane 2 : 30 ug of mouse embryonic fibroblast total cell extract.Lane 3 : 30 ug of mouse embryonic fibroblast total cell extract, with the p19ARF gene knocked out as a negative control.Performed under reducing conditions.

Anti-CDKN2A/p19ARF antibody - ab126879 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-CDKN2A/p19ARF antibody (ab126879) at 0.3 µg/ml + Mouse liver lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-CDKN2A/p19ARF antibody [12-A1] - ab26911 from Abcam

Prices $379.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 12-A1
Lane 1 : MarkerLanes 2 - 3 : Anti-CDKN2A/p19ARF antibody [12-A1] (ab26911) at 1 µg/mlLane 1 : As aboveLane 2 : mouse embryonic fibroblast total cell extract, with the p19ARF gene knocked out as a negative control at 20 µgLane 3 : mouse embryonic fibroblast total cell extract at 20 µgSecondaryLanes 2 - 3 : Rat IgG secondary antibody (ab28447) at 1/10000 dilutionPerformed under reducing conditions.

Anti-CDKN2A/p19ARF antibody [12-A1] - BSA and Azide free - ab175582 from Abcam

Prices $372.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 12-A1

Anti-CDKN2A/p19ARF antibody [5-C3] - ab26696 from Abcam

Prices $391.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 5-C3
All lanes : Anti-CDKN2A/p19ARF antibody [5-C3] (ab26696)Lane 1 : Total cell lysate from NIH3T3 cells with Arf gene deletedLane 2 : MEF total cell lysateSecondaryanti-rat IgG-HRP

Anti-CDKN2A/p19ARF antibody [5-C3] - BSA and Azide free - ab174939 from Abcam

Prices $372.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 5-C3

p19ARF Antibody - NB200-106 from Novus Biologicals

Prices $99.00, $299.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: p19ARF Antibody [NB200-106] - WB analysis of p19ARF in 1. NIH/3T3 and B. MEF cell lysate.

p19ARF Antibody (5-C3-1) - NB200-174 from Novus Biologicals

Prices $99.00, $299.00
Sizes 25 µl, 100 µl
Host Rat
Clonality Monoclonal
Clone 5-C3-1
Western Blot: p19ARF Antibody (5-C3-1) [NB200-174] - Total cell lysates (250 ug) from NIH3T3 cells which have deleted the Arf gene (Lanes 5) and from NIH3T3 cells expressing an HA-tagged version of p19Arf (lanes 3, 4) were incubated with control rat IgG (Lanes 3), or NB200-174 (lanes 4, 5) and protein G- Sepharose. Precipitated proteins were resolved by SDS-PAGE and analysed by Western blotting using an anti-HA antibody. Unprecipitated total cell lysates (25 ug, equivalent to 10% of immunoprecipitation) from Arf null NIH3T3 cells (Lanes 1) and HA- p19Arf expressing cells (Lanes 2) were also analysed by Western blotting, as input controls.

p19ARF Antibody (12-A1-1) - NB200-169 from Novus Biologicals

Prices $129.00, $299.00
Sizes 25 µl, 100 µl
Host Rat
Clonality Monoclonal
Clone 12-A1-1
Western Blot: p19ARF Antibody (12-A1-1) [NB200-169] - Analysis of endogenous p19Arf using NB200-169. Total cell lysates (25 ug) from NIH3T3 cells, which have deleted the Arf gene (Lanes 1) and from wild type mouse embryo fibroblasts (MEFs) at passage 6, which express p19Arf (Lanes 2), were resolved by SDS-PAGE. The membrane was probed with 1ug/ml purified p19Arf (NB200-169).

p19ARF Antibody - NBP2-27550 from Novus Biologicals

Prices $259.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: p19ARF Antibody [NBP2-27550] - (0.3 ug/ml) Analysis of Mouse Liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

p19ARF Antibody (5-C3-1) [HRP] - NB200-174H from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rat
Clonality Monoclonal
Clone 5-C3-1

p19ARF Antibody (5-C3-1) [DyLight 650] - NB200-174C from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rat
Clonality Monoclonal
Clone 5-C3-1

p19ARF Antibody (5-C3-1) [DyLight 488] - NB200-174G from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rat
Clonality Monoclonal
Clone 5-C3-1

p19ARF Antibody (5-C3-1) [DyLight 550] - NB200-174R from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rat
Clonality Monoclonal
Clone 5-C3-1

p19ARF Antibody (5-C3-1) [Biotin] - NB200-174B from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Rat
Clonality Monoclonal
Clone 5-C3-1

p19ARF Antibody (5-C3-1) [Allophycocyanin] - NB200-174APC from Novus Biologicals

Prices $329.00
Sizes 100 tests
Host Rat
Clonality Monoclonal
Clone 5-C3-1

p19ARF Antibody (5-C3-1) [Alexa Fluor (R) 700] - NB200-174AF700 from Novus Biologicals

Prices $319.00
Sizes 100 tests
Host Rat
Clonality Monoclonal
Clone 5-C3-1

p19ARF Antibody (5-C3-1) [Alexa Fluor (R) 647] - NB200-174AF647 from Novus Biologicals

Prices $319.00
Sizes 100 tests
Host Rat
Clonality Monoclonal
Clone 5-C3-1

p19ARF Antibody (5-C3-1) [Alexa Fluor (R) 488] - NB200-174AF488 from Novus Biologicals

Prices $329.00
Sizes 100 tests
Host Rat
Clonality Monoclonal
Clone 5-C3-1
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