Cdkn2a

Gene Symbol Cdkn2a
Entrez Gene 12578
Alt Symbol ARF-INK4a, Arf, INK4a-ARF, Ink4a/Arf, MTS1, Pctr1, p16, p16(INK4a), p16INK4a, p19<ARF>, p19ARF
Species Mouse
Gene Type protein-coding
Description cyclin-dependent kinase inhibitor 2A
Other Description CDK4I|cdkn2a|cyclin-dependent kinase 4 inhibitor A|cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4)|cyclin-dependent kinase inhibitor 2A, isoforms 1/2|cyclin-dependent kinase inhibitor protein|mitochondrial smARF|p16-INK4|p16-INK4a
Swissprots Q9QWH8 Q9QWH6 Q792X7 Q78E39 P97510 Q78E57 P51480 A2ANM1 Q9QXC7 O89088 Q6PEA2 P97937 Q4U255 A2ANM2 Q64364 Q9QWH7 Q9R051
Accessions AAB39600 AAB61416 AAC00051 AAC00052 AAC00053 AAC00054 AAC52987 AAD00223 AAD00224 AAD00225 AAD00226 AAD00227 AAD00228 AAD00229 AAD00230 AAD00231 AAD11438 AAD33245 AAK83159 CAB65598 CAI84565 EDL30951 P51480 Q64364 AB221638 AF044335 AAC08962 AF044336 AAC08963 AK155307 BAE33180 BC058190 AAH58190 EU071702 ABS85193 L76092 AAC42080 L76150 AAA85453 S80650 AAB35770 NM_001040654 NP_001035744 NM_009877 NP_034007
Function Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2- induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination (By similarit
Subcellular Location Nucleus, nucleolus {ECO:0000250|UniProtKB:Q8N726, ECO:0000269|PubMed:10359817, ECO:0000269|PubMed:15567177, ECO:0000269|PubMed:15601844, ECO:0000269|PubMed:8521522}. Nucleus, nucleoplasm {ECO:0000250}.
Top Pathways Cell cycle, Glioma, Pancreatic cancer, Non-small cell lung cancer, Bladder cancer

Cyclin-dependent kinase inhibitor 2A, isoforms 1/2, Cdkn2a, Mouse, ELISA Kit - E0794m from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t

Mouse CDKN2A ELISA Kit - MC0534 from NeoScientific

Category ELISA Kit
Prices $495.00
Sizes 96 t

Mouse CDKN2A(Cyclin Dependent Kinase Inhibitor 2A) ELISA Kit - E-EL-M0117 from Elabscience

Category ELISA Kit
Sensitivity 23.44 pg/mL
Range 39.06—2500 pg/mL

Mouse CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) CLIA Kit - E-CL-M0092 from Elabscience

Category CLIA Kit
Sensitivity 9.38 pg/mL
Range Average Recovery (%)

Mouse Cyclin Dependent Kinase Inhibitor 2A ELISA - E03C0527 from BlueGene Biotech

Category ELISA Kit

Mouse CDKN2A(Cyclin Dependent Kinase Inhibitor 2A) ELISA Kit - E-EL-M0117 from Iwai North America Inc.

Category ELISA Kit
Prices $580.00
Sizes 1 kit
Sensitivity 23.44 pg/mL
Range 39.06~2500 pg/mL

Mouse CDKN2A ELISA Kit - abx153806 from Abbexa

Category ELISA Kit
Sensitivity 0.108 ng/ml
Range 0.313 ng/ml - 20 ng/ml

Mouse CDKN2A ELISA Kit - abx571983 from Abbexa

Category ELISA Kit
Sensitivity 0.108 ng/ml
Range 0.313 ng/ml - 20 ng/ml

CDKN2A - EKM1830 from Nordic BioSite

Sensitivity 23.438pg/ml
Range 39.063-2500pg/ml

Mouse Cdkn2a ELISA Kit - E047827 from Biobool

Category ELISA Kit
Sensitivity 23.438pg/mL

Mouse CDKN2A ELISA Kit - EMC0534 from ABclonal

Category ELISA Kit
Prices $495.00
Sizes 96 t

CDKN2A ELISA Kit (Mouse) (OKCD02445) - OKCD02445 from Aviva Systems Biology

Category ELISA Kit
Prices $515.00
Sizes 20 ng
Sensitivity 0.108 ng/mL
Range 0.312-20 ng/mL

Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3, ELISA Kit - MBS765099 from MyBioSource

Category ELISA Kit
Prices $295.00, $390.00, $1,615.00, $3,015.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.375ng/ml
Range 0.625-40ng/ml

Cyclin Dependent Kinase Inhibitor 2A (CDKN2A), ELISA Kit - MBS450199 from MyBioSource

Category ELISA Kit
Prices $395.00, $520.00, $2,275.00, $4,420.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity <0.108ng/mL
Range 0.312-20ng/mL

Cyclin-dependent kinase inhibitor 2A, ELISA Kit - MBS2881678 from MyBioSource

Category ELISA Kit
Prices $380.00, $500.00, $2,170.00, $3,840.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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