| Gene Symbol |
Cdkn2a
|
| Entrez Gene |
12578
|
| Alt Symbol |
ARF-INK4a, Arf, INK4a-ARF, Ink4a/Arf, MTS1, Pctr1, p16, p16(INK4a), p16INK4a, p19<ARF>, p19ARF
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
cyclin-dependent kinase inhibitor 2A
|
| Other Description |
CDK4I|cdkn2a|cyclin-dependent kinase 4 inhibitor A|cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4)|cyclin-dependent kinase inhibitor 2A, isoforms 1/2|cyclin-dependent kinase inhibitor protein|mitochondrial smARF|p16-INK4|p16-INK4a
|
| Swissprots |
Q9QWH8 Q9QWH6 Q792X7 Q78E39 P97510 Q78E57 P51480 A2ANM1 Q9QXC7 O89088 Q6PEA2 P97937 Q4U255 A2ANM2 Q64364 Q9QWH7 Q9R051
|
| Accessions |
AAB39600 AAB61416 AAC00051 AAC00052 AAC00053 AAC00054 AAC52987 AAD00223 AAD00224 AAD00225 AAD00226 AAD00227 AAD00228 AAD00229 AAD00230 AAD00231 AAD11438 AAD33245 AAK83159 CAB65598 CAI84565 EDL30951 P51480 Q64364 AB221638 AF044335 AAC08962 AF044336 AAC08963 AK155307 BAE33180 BC058190 AAH58190 EU071702 ABS85193 L76092 AAC42080 L76150 AAA85453 S80650 AAB35770 NM_001040654 NP_001035744 NM_009877 NP_034007
|
| Function |
Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2- induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination (By similarit
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000250|UniProtKB:Q8N726, ECO:0000269|PubMed:10359817, ECO:0000269|PubMed:15567177, ECO:0000269|PubMed:15601844, ECO:0000269|PubMed:8521522}. Nucleus, nucleoplasm {ECO:0000250}.
|
| Top Pathways |
Cell cycle, Glioma, Pancreatic cancer, Non-small cell lung cancer, Bladder cancer
|