| Gene Symbol | AP1AR |
|---|---|
| Entrez Gene | 55435 |
| Alt Symbol | 2C18, C4orf16, GBAR, PRO0971, gamma-BAR |
| Species | Human |
| Gene Type | protein-coding |
| Description | adaptor-related protein complex 1 associated regulatory protein |
| Other Description | AP-1 complex-associated regulatory protein|adapter-related protein complex 1-associated regulatory protein|adaptor-related protein complex 1-associated regulatory protein|gadkin|gamma-1-adaptin brefeldin A resistance protein|gamma-A1-adaptin and kinesin interactor|gamma1-adaptin brefeldin A resistance protein, gamma-BAR |
| Swissprots | Q9P1L4 Q96GG6 Q63HQ0 Q9H0V0 B2RCV7 |
| Accessions | AAY40962 EAX06268 EAX06269 EAX06270 EAX06271 EAX06272 Q63HQ0 AF116612 AAF71037 AI273122 AK310787 AK315299 BAG37704 AL136628 CAB66563 AM392774 CAL37652 AM393046 CAL37924 AM393154 CAL38032 AM393604 CAL38480 AM393708 CAL38584 BC009485 AAH09485 BM974015 BX647702 CAH56145 DA463845 EU831660 ACE87260 EU831743 ACE86577 XM_005263116 XP_005263173 XM_011532100 XP_011530402 NM_001128426 NP_001121898 NM_018569 NP_061039 |
| Function | Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus- end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo- lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex. {ECO:0000269|PubMed:15775984, ECO:0000269|PubMed:19706427, ECO:0000269|PubMed:21525240, ECO:0000269|PubMed:22689987}. |
| Subcellular Location | Golgi apparatus, trans-Golgi network. Late endosome. Early endosome. Note=Localizes to the juxta-nuclear Golgi region and to tubular structures throughout the cytoplasm, which are highly mobile and cycle between the juxta-nuclear area and the cell periphery. |
AP1AR CRISPR/Cas9 KO Plasmid (h) - sc-412536 from Santa Cruz Biotechnology
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AP1AR HDR Plasmid (h) - sc-412536-HDR from Santa Cruz Biotechnology
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AP1AR Double Nickase Plasmid (h) - sc-412536-NIC from Santa Cruz Biotechnology
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AP1AR Double Nickase Plasmid (h2) - sc-412536-NIC-2 from Santa Cruz Biotechnology
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AP1AR CRISPR Activation Plasmid (h) - sc-412536-ACT from Santa Cruz Biotechnology
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AP1AR CRISPR Activation Plasmid (h2) - sc-412536-ACT-2 from Santa Cruz Biotechnology
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AP1AR Lentiviral Activation Particles (h) - sc-412536-LAC from Santa Cruz Biotechnology
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AP1AR Lentiviral Activation Particles (h2) - sc-412536-LAC-2 from Santa Cruz Biotechnology
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AP1AR siRNA (h) - sc-89134 from Santa Cruz Biotechnology
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AP1AR shRNA Plasmid (h) - sc-89134-SH from Santa Cruz Biotechnology
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AP1AR shRNA (h) Lentiviral Particles - sc-89134-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU071691 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3278 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3278 from Sigma-Aldrich
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AP1AR siRNA (Human) - CRJ0702 from Cohesion Biosciences
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AP1AR - MBS8203845 from MyBioSource
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shRNA set against Human AP1AR (NM_018569.4) - SHH237722 from Creative biogene
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Human AP1AR siRNA - orb271203 from Biorbyt
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AP1AR shRNA Plasmid (Human) - CHJ0702 from Cohesion Biosciences
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AP1AR miRNA 3'UTR clone - MiUTR3H-11508 from Creative biogene
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AP1AR miRNA 3'UTR clone - MiUTR3H-11509 from Creative biogene
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