| Gene Symbol | AP1AR |
|---|---|
| Entrez Gene | 55435 |
| Alt Symbol | 2C18, C4orf16, GBAR, PRO0971, gamma-BAR |
| Species | Human |
| Gene Type | protein-coding |
| Description | adaptor-related protein complex 1 associated regulatory protein |
| Other Description | AP-1 complex-associated regulatory protein|adapter-related protein complex 1-associated regulatory protein|adaptor-related protein complex 1-associated regulatory protein|gadkin|gamma-1-adaptin brefeldin A resistance protein|gamma-A1-adaptin and kinesin interactor|gamma1-adaptin brefeldin A resistance protein, gamma-BAR |
| Swissprots | Q9P1L4 Q96GG6 Q63HQ0 Q9H0V0 B2RCV7 |
| Accessions | AAY40962 EAX06268 EAX06269 EAX06270 EAX06271 EAX06272 Q63HQ0 AF116612 AAF71037 AI273122 AK310787 AK315299 BAG37704 AL136628 CAB66563 AM392774 CAL37652 AM393046 CAL37924 AM393154 CAL38032 AM393604 CAL38480 AM393708 CAL38584 BC009485 AAH09485 BM974015 BX647702 CAH56145 DA463845 EU831660 ACE87260 EU831743 ACE86577 XM_005263116 XP_005263173 XM_011532100 XP_011530402 NM_001128426 NP_001121898 NM_018569 NP_061039 |
| Function | Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus- end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo- lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex. {ECO:0000269|PubMed:15775984, ECO:0000269|PubMed:19706427, ECO:0000269|PubMed:21525240, ECO:0000269|PubMed:22689987}. |
| Subcellular Location | Golgi apparatus, trans-Golgi network. Late endosome. Early endosome. Note=Localizes to the juxta-nuclear Golgi region and to tubular structures throughout the cytoplasm, which are highly mobile and cycle between the juxta-nuclear area and the cell periphery. |
AP-1 complex-associated regulatory protein (C4orf16), Human, ELISA Kit - E01A1800 from ARP American Research Products
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AP 1 complex associated regulatory protein (C4orf16), ELISA Kit - MBS7215066 from MyBioSource
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AP-1 complex-associated regulatory protein (C4orf16), ELISA Kit - MBS7250188 from MyBioSource
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AP-1 complex-associated regulatory protein (C4orf16), ELISA Kit - MBS7245336 from MyBioSource
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AP-1 complex-associated regulatory protein (C4orf16), ELISA Kit - MBS7205916 from MyBioSource
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AP-1 complex-associated regulatory protein (C4orf16), ELISA Kit - MBS7215138 from MyBioSource
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AP-1 complex-associated regulatory protein (C4orf16), ELISA Kit - MBS7208761 from MyBioSource
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AP-1 complex-associated regulatory protein (C4orf16), ELISA Kit - MBS7224408 from MyBioSource
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AP-1 complex-associated regulatory protein (C4orf16), ELISA Kit - MBS7218555 from MyBioSource
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AP-1 complex-associated regulatory protein (C4orf16), ELISA Kit - MBS7250047 from MyBioSource
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AP-1 complex-associated regulatory protein (C4orf16), ELISA Kit - MBS7233411 from MyBioSource
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AP-1 complex-associated regulatory protein (C4orf16), ELISA Kit - MBS7227571 from MyBioSource
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AP-1 complex-associated regulatory protein (C4orf16), ELISA Kit - MBS7249618 from MyBioSource
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chromosome 4 open reading frame 16, ELISA Kit - MBS9335773 from MyBioSource
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Human C4orf16 ELISA Kit - E003157 from Biobool
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Human AP1AR ELISA Kit - E075383 from Biobool
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