CD276

Gene Symbol CD276
Entrez Gene 80381
Alt Symbol 4Ig-B7-H3, B7-H3, B7H3, B7RP-2
Species Human
Gene Type protein-coding
Description CD276 molecule
Other Description B7 homolog 3|CD276 antigen|costimulatory molecule
Swissprots Q8NCB6 Q6P5Y4 Q8NBI8 Q5ZPR3 Q9BXR1 Q8NC34 Q6UXI2
Accessions CAC18949 CAC35428 EAW77933 EAW77934 Q5ZPR3 AF302102 AAK15438 AJ583695 CAE47548 AJ583696 AK074849 BAC11243 AK074997 BAC11344 AK075549 BAC11692 AK291721 BAF84410 AK292711 BAF85400 AK296358 BAG59038 AK298522 BAG60725 AK309728 AL360136 AY358343 AAQ88709 BC011578 BC062581 AAH62581 BQ278722 CA420873 CB529187 XM_005254700 XP_005254757 XM_011522095 XP_011520397 XM_011522096 XP_011520398 NM_001024736 NP_001019907 NM_025240 NP_079516
Function May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. {ECO:0000269|PubMed:11224528, ECO:0000269|PubMed:12906861, ECO:0000269|PubMed:14764704, ECO:0000269|PubMed:15314238, ECO:0000269|PubMed:15682454, ECO:0000269|PubMed:15961727}.
Subcellular Location Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue Specificity Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta. {ECO:0000269|PubMed:11224528, ECO:0000269|PubMed:14764704, ECO:0000269|PubMed:15961727, ECO:0000269|PubMed:16049332, ECO:0000269|PubMed:16274630}.
Top Pathways Cell adhesion molecules (CAMs)

B7-H3 CRISPR/Cas9 KO Plasmid (h) - sc-402032 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

B7-H3 HDR Plasmid (h) - sc-402032-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

B7-H3 Double Nickase Plasmid (h) - sc-402032-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

B7-H3 Double Nickase Plasmid (h2) - sc-402032-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

B7-H3 CRISPR Activation Plasmid (h) - sc-402032-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

B7-H3 CRISPR Activation Plasmid (h2) - sc-402032-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

B7-H3 Lentiviral Activation Particles (h) - sc-402032-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

B7-H3 Lentiviral Activation Particles (h2) - sc-402032-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

B7-H3 siRNA (h) - sc-45444 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

B7-H3 shRNA Plasmid (h) - sc-45444-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

B7-H3 shRNA (h) Lentiviral Particles - sc-45444-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU081271 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN5708 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5708 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09990 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr09990

CD276 siRNA (Human) - CRJ2878 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CD276 - MBS8220239 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CD276 (NM_025240.2) - SHH258841 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human CD276(NM_025240.2) - SHG156153 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human CD276(NM_001024736.1) - SHG156355 from Creative biogene

Category siRNA
Species Reactivities Human

Human CD276 siRNA - orb273379 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CD276 shRNA Plasmid (Human) - CHJ2878 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CD276 miRNA 3'UTR clone - MiUTR1H-01861 from Creative biogene

Species Reactivities Human

CD276 miRNA 3'UTR clone - MiUTR1H-01862 from Creative biogene

Species Reactivities Human
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