CD276
| Gene Symbol | CD276 |
|---|---|
| Entrez Gene | 80381 |
| Alt Symbol | 4Ig-B7-H3, B7-H3, B7H3, B7RP-2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CD276 molecule |
| Other Description | B7 homolog 3|CD276 antigen|costimulatory molecule |
| Swissprots | Q8NCB6 Q6P5Y4 Q8NBI8 Q5ZPR3 Q9BXR1 Q8NC34 Q6UXI2 |
| Accessions | CAC18949 CAC35428 EAW77933 EAW77934 Q5ZPR3 AF302102 AAK15438 AJ583695 CAE47548 AJ583696 AK074849 BAC11243 AK074997 BAC11344 AK075549 BAC11692 AK291721 BAF84410 AK292711 BAF85400 AK296358 BAG59038 AK298522 BAG60725 AK309728 AL360136 AY358343 AAQ88709 BC011578 BC062581 AAH62581 BQ278722 CA420873 CB529187 XM_005254700 XP_005254757 XM_011522095 XP_011520397 XM_011522096 XP_011520398 NM_001024736 NP_001019907 NM_025240 NP_079516 |
| Function | May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. {ECO:0000269|PubMed:11224528, ECO:0000269|PubMed:12906861, ECO:0000269|PubMed:14764704, ECO:0000269|PubMed:15314238, ECO:0000269|PubMed:15682454, ECO:0000269|PubMed:15961727}. |
| Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Tissue Specificity | Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta. {ECO:0000269|PubMed:11224528, ECO:0000269|PubMed:14764704, ECO:0000269|PubMed:15961727, ECO:0000269|PubMed:16049332, ECO:0000269|PubMed:16274630}. |
| Top Pathways | Cell adhesion molecules (CAMs) |
CD276 peptide - ab182198 from Abcam
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Human CD276 protein fragment - ab134865 from Abcam
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CD276 / B7-H3 Antibody Blocking Peptide - LS-E1935 from LifeSpan Bioscience
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CD276 / B7-H3 Antibody Blocking Peptide - LS-E23314 from LifeSpan Bioscience
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CD276-Antibody-C-term-Blocking-peptide - BP12782b from Abgent, a WuXi AppTec company
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Recombinant Human B7-H3 (4Ig)/B7-H3b - 2318-B3-050 from R&D Systems
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Recombinant Human B7-H3 (4Ig)/B7-H3b, CF - 2318-B3-050/CF from R&D Systems
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Recombinant Human B7-H3 - 1949-B3-050 from R&D Systems
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Recombinant Human B7-H3, CF - 1949-B3-050/CF from R&D Systems
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Recombinant Human B7-H3 Fc Chimera, CF - 1027-B3-100 from R&D Systems
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Human B7-H3 (Fc Tag) protein - orb232261 from Biorbyt
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Human CD276 (His Tag) protein - orb232262 from Biorbyt
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Human B7H3 protein - orb84333 from Biorbyt
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CD276 / B7H3 - H00080381-H01 from Acris Antibodies
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CD276 / B7H3 - H00080381-H02 from Acris Antibodies
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CD276 / B7H3 - H00080381-H04 from Acris Antibodies
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CD276 fusion protein - ag6006 from Proteintech Group
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Recombinant Human CD276, His tagged - CD276-3884H from Creative Biomart
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Recombinant Human CD276, GST-tagged - CD276-10935H from Creative Biomart
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Recombinant Human CD276, Fc-tagged - CD276-183H from Creative Biomart
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Recombinant Human CD276, MIgG2a Fc-tagged - CD276-2001H from Creative Biomart
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Recombinant Human CD276, HIgG1 Fc-tagged - CD276-2002H from Creative Biomart
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Recombinant Human CD276, Fc Chimera - CD276-756H from Creative Biomart
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Recombinant Human CD276, His-tagged - CD276-757H from Creative Biomart
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Recombinant Human CD276, Fc-tagged - CD276-542H from Creative Biomart
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