| Gene Symbol |
CD276
|
| Entrez Gene |
80381
|
| Alt Symbol |
4Ig-B7-H3, B7-H3, B7H3, B7RP-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CD276 molecule
|
| Other Description |
B7 homolog 3|CD276 antigen|costimulatory molecule
|
| Swissprots |
Q8NCB6 Q6P5Y4 Q8NBI8 Q5ZPR3 Q9BXR1 Q8NC34 Q6UXI2
|
| Accessions |
CAC18949 CAC35428 EAW77933 EAW77934 Q5ZPR3 AF302102 AAK15438 AJ583695 CAE47548 AJ583696 AK074849 BAC11243 AK074997 BAC11344 AK075549 BAC11692 AK291721 BAF84410 AK292711 BAF85400 AK296358 BAG59038 AK298522 BAG60725 AK309728 AL360136 AY358343 AAQ88709 BC011578 BC062581 AAH62581 BQ278722 CA420873 CB529187 XM_005254700 XP_005254757 XM_011522095 XP_011520397 XM_011522096 XP_011520398 NM_001024736 NP_001019907 NM_025240 NP_079516
|
| Function |
May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. {ECO:0000269|PubMed:11224528, ECO:0000269|PubMed:12906861, ECO:0000269|PubMed:14764704, ECO:0000269|PubMed:15314238, ECO:0000269|PubMed:15682454, ECO:0000269|PubMed:15961727}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta. {ECO:0000269|PubMed:11224528, ECO:0000269|PubMed:14764704, ECO:0000269|PubMed:15961727, ECO:0000269|PubMed:16049332, ECO:0000269|PubMed:16274630}.
|
| Top Pathways |
Cell adhesion molecules (CAMs)
|
![Western Blot: CD276 Overexpression Lysate (Adult Normal) [NBP2-06214] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CD276.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/797_CD276%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06214-img0001.jpg)