CD276

Gene Symbol	CD276
Entrez Gene	80381
Alt Symbol	4Ig-B7-H3, B7-H3, B7H3, B7RP-2
Species	Human
Gene Type	protein-coding
Description	CD276 molecule
Other Description	B7 homolog 3|CD276 antigen|costimulatory molecule
Swissprots	Q8NCB6 Q6P5Y4 Q8NBI8 Q5ZPR3 Q9BXR1 Q8NC34 Q6UXI2
Accessions	CAC18949 CAC35428 EAW77933 EAW77934 Q5ZPR3 AF302102 AAK15438 AJ583695 CAE47548 AJ583696 AK074849 BAC11243 AK074997 BAC11344 AK075549 BAC11692 AK291721 BAF84410 AK292711 BAF85400 AK296358 BAG59038 AK298522 BAG60725 AK309728 AL360136 AY358343 AAQ88709 BC011578 BC062581 AAH62581 BQ278722 CA420873 CB529187 XM_005254700 XP_005254757 XM_011522095 XP_011520397 XM_011522096 XP_011520398 NM_001024736 NP_001019907 NM_025240 NP_079516
Function	May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. {ECO:0000269|PubMed:11224528, ECO:0000269|PubMed:12906861, ECO:0000269|PubMed:14764704, ECO:0000269|PubMed:15314238, ECO:0000269|PubMed:15682454, ECO:0000269|PubMed:15961727}.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue Specificity	Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta. {ECO:0000269|PubMed:11224528, ECO:0000269|PubMed:14764704, ECO:0000269|PubMed:15961727, ECO:0000269|PubMed:16049332, ECO:0000269|PubMed:16274630}.
Top Pathways	Cell adhesion molecules (CAMs)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CD276 / B7-H3 ELISA Kit (Sandwich ELISA) - LS-F7284 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.122 ng/ml Range 0.313-20 ng/ml

Human CD276 / B7-H3 ELISA Kit (Sandwich ELISA) - LS-F11075 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 0.78 Range 0.313-20 ng/ml

Human B7-H3 Quantikine ELISA Kit - DB7H30 from R&D Systems Category ELISA Kit Prices $519.00 Sizes 1 kit Sensitivity 0.274 ng/mL Range 0.8 - 50 ng/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Urine)

Quantikine Immunoassay Control Set 725 for Human B7-H3 - QC47 from R&D Systems Category ELISA Kit Prices $125.00 Sizes 1 each

Human CD276 ELISA Kit - abx150999 from Abbexa Category ELISA Kit Sensitivity 0.136 ng/ml Range 0.313 ng/ml - 20 ng/ml

Cluster of Differentiation 276, CD276, Human, ELISA Kit - E-EL-H1484 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.469 Range 0.781-50ng/mL

CD276 antigen, CD276, Human, ELISA Kit - E8942h from ARP American Research Products Category ELISA Kit Prices $476.00 Sizes 96 t Range 0.78-50 ng/mL

Cluster Of Differentiation 276 (CD276), Human, ELISA Kit - SEA781Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 0.115ng/mL Range 0.312-20ng/mL

Soluble CD276, sCD276/sB7-H3, Human, ELISA Kit - CSB-E14285h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.78 ng/ml Range 3.12 ng/ml-200 ng/ml

CD276 (Human) Matched Antibody Pair - H00080381-AP41 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Custom Human B7-H3 ELISA - ELH-B7H3 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Cluster of Differentiation 276, ELISA Kit - MBS093656 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cluster of Differentiation 276, ELISA Kit - MBS059358 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cluster of Differentiation 276, ELISA Kit - MBS077297 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cluster of Differentiation 276, ELISA Kit - MBS083963 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cluster Of Differentiation 276 (CD276), ELISA Kit - MBS2020367 from MyBioSource Category ELISA Kit Prices $345.00, $515.00, $695.00, $2,840.00, $5,180.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.136ng/mL. Range 0.313-20ng/mL

Human B7-H3 ELISA Kit - DEIA2941 from Creative Diagnostics Category ELISA Kit Sensitivity Thirty-two assays were evaluated and the minimum detectable dose (MDD) of B7-H3 ranged from 0.037-0.274 ng/mL. The mean MDD was 0.160 ng/mL. The MDD was determined by adding two standard deviations to the mean optical density value of twenty zero stand

Human CD276(Cluster of Differentiation 276) ELISA Kit - E-EL-H1484 from Elabscience Category ELISA Kit Sensitivity 0.47 ng/mL Range 0.78—50 ng/mL

Human CD276 (Cluster of Differentiation 276) CLIA Kit - E-CL-H0955 from Elabscience Category CLIA Kit Sensitivity 0.09 ng/mL Range Average Recovery (%)

B7-H3 Gene, ELISA Kit - MBS099079 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

B7-H3 Gene, ELISA Kit - MBS023560 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

B7-H3 Gene, ELISA Kit - MBS021298 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

B7-H3 Gene, ELISA Kit - MBS026162 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

B7-H3 gene, ELISA Kit - MBS743219 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

B7-H3 Gene, ELISA Kit - MBS024371 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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