ANTXR1

Gene Symbol ANTXR1
Entrez Gene 84168
Alt Symbol ATR, GAPO, TEM8
Species Human
Gene Type protein-coding
Description anthrax toxin receptor 1
Other Description 2310008J16Rik|2810405N18Rik|tumor endothelial marker 8
Swissprots Q4ZFV6 J7K7G4 Q96P02 J7KF88 A8K7U8 Q9NVP3 Q9H6X2 Q53QD8
Accessions AAX88860 AAY24067 CAL60148 EAW99855 EAW99856 EAW99857 EAW99858 Q9H6X2 AF090095 AF279145 AAK52094 AF421380 AAL26496 AK001463 BAA91707 AK002160 AK025429 BAB15128 AK126783 AK223273 BAD96993 AK292113 BAF84802 AK309553 BC012074 AAH12074 BC012475 AAH12475 BU687536 CF126791 DC360415 DC361072 EU832615 ACE87706 EU832687 ACE87019 HQ447200 ADQ31687 JX424838 AFQ94038 JX424839 AFQ94039 XM_011533124 XP_011531426 XR_939725 XR_939726 NM_018153 NP_060623 NM_032208 NP_115584 NM_053034 NP_444262
Function Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. {ECO:0000269|PubMed:15777794, ECO:0000269|PubMed:16762926}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:16762926}; Single-pass type I membrane protein {ECO:0000269|PubMed:16762926}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:16762926}; Single-pass type I membrane protein {ECO:0000269|PubMed:16762926}. Cell projection, filopodium membrane {ECO:0000269|PubMed:16762926}; Single-pass type I membrane protein {ECO:0000269|PubMed:16762926}. Note=At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia.
Tissue Specificity Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells. {ECO:0000269|PubMed:15777794}.

TEM8 (C-14) - sc-19761 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TEM8 (H-140) - sc-15406 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TEM8 (H-140): sc-15406. Western blot analysis of TEM8 isoform expression in P 23 whole cell lysate.

TEM8 (N-19) - sc-19759 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TEM8 (R-13) - sc-19763 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TEM8 (R-13): sc-19763. Western blot analysis of TEM8 expression in K-562 (A) and Raji (B) whole cell lysates.

TEM8 (A-16) - sc-19762 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TEM8 (200C1339) - sc-52959 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
TEM8 (200C1339): sc-52959. Western blot analysis of TEM8 expression in human PBL whole cell lysate.

TEM8 (4H261) - sc-73136 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
TEM8 (4H261): sc-73136. Western blot analysis of TEM8 expression in Jurkat whole cell lysate.

TEM8 (A-25) - sc-130893 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
TEM8 (A-25): sc-130893. Western blot analysis of TEM8 expression in HeLa whole cell lysate.

Anti-TEM8 antibody - ab21270 from Abcam

Prices $391.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TEM8 antibody - ab19387 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab19387 stained HepG2 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab19387, 1µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-TEM8 antibody - ab21269 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-TEM8 antibody (ab21269) at 0.5 µg/mlLane 2 : Anti-TEM8 antibody (ab21269) at 1 µg/mlLane 3 : Anti-TEM8 antibody (ab21269) at 2 µg/mlLane 1 : K562 cell lysateLane 2 : K562 cell lysateLane 3 : K562 cell lysate

Anti-TEM8 antibody - ab128579 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TEM8 antibody (ab128579) at 1/1000 dilutionLane 1 : K562 cell lysateLane 2 : HepG2 cell lysate

Anti-TEM8 antibody - ab34268 from Abcam

Prices $370.00
Sizes 125 µl
Host Rabbit
Clonality Polyclonal

Anti-TEM8 antibody - ab15724 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-TEM8 antibody [200C1339] - ab13798 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 200C1339
Western blot detection of TEM8 in TEM8 transfected cell lysate using ab13798 at 1 µg/ml.

Anti-ANTXR1 / TEM8 Antibody - LS-C346112 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence blot of HeLa cell using ANTXR1 antibody. Blue: DAPI for nuclear staining.

Anti-ANTXR1 / TEM8 Antibody (Internal) - LS-C12069 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ANTXR1 / TEM8 Antibody (C-Terminus) - LS-C12070 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ANTXR1 / TEM8 Antibody - LS-C39569 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-ANTXR1 / TEM8 Antibody (aa2381-2644) - LS-C42748 from LifeSpan Bioscience

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ANTXR1 / TEM8 Antibody (aa481-497, clone 200C1339(SB20)) - LS-C596 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 200C1339(SB20)
Western blot detection of TEM8 in TEM8 transfected cell lysate using antibody at 1 ug/ml.

Anti-ANTXR1 / TEM8 Antibody - LS-C96153 from LifeSpan Bioscience

Prices $385.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal

Anti-ANTXR1 / TEM8 Antibody - LS-C96154 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ANTXR1 / TEM8 Antibody - LS-C96155 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ANTXR1 / TEM8 Antibody - LS-C96156 from LifeSpan Bioscience

Prices $385.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal
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