| Gene Symbol |
CIT
|
| Entrez Gene |
11113
|
| Alt Symbol |
CRIK, STK21
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
citron rho-interacting serine/threonine kinase
|
| Other Description |
citron (rho-interacting, serine/threonine kinase 21)|citron Rho-interacting kinase|serine/threonine kinase 21|serine/threonine-protein kinase 21
|
| Swissprots |
Q9UPZ7 O14578 Q6XUH8 Q86UQ9 Q2M5E1
|
| Accessions |
AAB71327 EAW98155 EAW98156 EAW98157 EAW98158 O14578 AB023166 BAA76793 AK123136 AY209000 AAP43922 AY257469 AAP13528 AY681966 AAV87216 BC008127 BC047647 BC156529 AAI56530 BC172522 AAI72522 XM_006719206 XP_006719269 XM_011537783 XP_011536085 XM_011537784 XP_011536086 XM_011537785 XP_011536087 XM_011537786 XP_011536088 XM_011537787 XP_011536089 XM_011537788 XP_011536090 XM_011537789 XP_011536091 XM_011537790 XP_011536092 XM_011537791 XP_011536093 XM_011537792 XP_011536094 NM_001206999 NP_001193928 NM_007174 NP_009105
|
| Function |
Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. {ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:21457715}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|