Sumo2

Gene Symbol	Sumo2
Entrez Gene	100689105
Alt Symbol	SMT3A, SMT3H2, SUMO-2, Sentrin-2, Smt3
Species	Hamster
Gene Type	protein-coding
Description	small ubiquitin-like modifier 2
Other Description	MIF2 suppressor\|SMT3 homolog 2\|SMT3 suppressor of mif two 3 homolog 2\|Ubiquitin-like protein SMT3A\|small ubiquitin-related modifier 2
Swissprots	Q6LDZ8
Accessions	Q6LDZ8 JI862782 JP054697 L79950 AAR24618 NM_001244144 NP_001231073
Function	Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX (By similarity). {ECO:0000250\|UniProtKB:P61956}.
Subcellular Location	Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000250}.
Top Pathways	RNA transport

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