| Gene Symbol |
Sumo2
|
| Entrez Gene |
100689105
|
| Alt Symbol |
SMT3A, SMT3H2, SUMO-2, Sentrin-2, Smt3
|
| Species |
Hamster
|
| Gene Type |
protein-coding
|
| Description |
small ubiquitin-like modifier 2
|
| Other Description |
MIF2 suppressor|SMT3 homolog 2|SMT3 suppressor of mif two 3 homolog 2|Ubiquitin-like protein SMT3A|small ubiquitin-related modifier 2
|
| Swissprots |
Q6LDZ8
|
| Accessions |
Q6LDZ8 JI862782 JP054697 L79950 AAR24618 NM_001244144 NP_001231073
|
| Function |
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX (By similarity). {ECO:0000250|UniProtKB:P61956}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000250}.
|
| Top Pathways |
RNA transport
|