| Gene Symbol | Sumo2 |
|---|---|
| Entrez Gene | 100689105 |
| Alt Symbol | SMT3A, SMT3H2, SUMO-2, Sentrin-2, Smt3 |
| Species | Hamster |
| Gene Type | protein-coding |
| Description | small ubiquitin-like modifier 2 |
| Other Description | MIF2 suppressor|SMT3 homolog 2|SMT3 suppressor of mif two 3 homolog 2|Ubiquitin-like protein SMT3A|small ubiquitin-related modifier 2 |
| Swissprots | Q6LDZ8 |
| Accessions | Q6LDZ8 JI862782 JP054697 L79950 AAR24618 NM_001244144 NP_001231073 |
| Function | Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX (By similarity). {ECO:0000250|UniProtKB:P61956}. |
| Subcellular Location | Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000250}. |
| Top Pathways | RNA transport |
Recombinant Cricetulus griseus Small ubiquitin-related modifier 2(SUMO2) - CSB-YP750454DXU CSB-EP750454DXU CSB-BP750454DXU CSB-MP750454DXU from Cusabio
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Small ubiquitin-related modifier 2 (SUMO2), Recombinant Protein - MBS1448163 from MyBioSource
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