| Gene Symbol | SPHK1 |
|---|---|
| Entrez Gene | 8877 |
| Alt Symbol | SPHK |
| Species | Human |
| Gene Type | protein-coding |
| Description | sphingosine kinase 1 |
| Other Description | SK 1|SPK 1 |
| Swissprots | Q9NYA1 Q9NY70 Q9HD92 Q96GK1 Q8N632 Q9NYL3 |
| Accessions | AAP35060 CAE90363 CAE90969 EAW89388 EAW89389 EAW89390 EAW89391 EAW89392 EAW89393 EAW89394 Q9NYA1 AF200328 AAG01980 AF238083 AAF73423 AF266756 AAF73470 AJ245504 CAB92131 AK022402 BAB14028 AK023393 BAB14558 AK095578 AK122781 BAG53725 AK225250 AK225258 AK292294 BAF84983 AK292614 BAF85303 BC004112 AAH04112 BC008040 AAH08040 BC009419 AAH09419 BC014439 AAH14439 BC030553 AAH30553 BP304783 DC384776 XM_005257766 XP_005257823 XM_011525439 XP_011523741 NM_001142601 NP_001136073 NM_001142602 NP_001136074 NM_021972 NP_068807 NM_182965 NP_892010 |
| Function | Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. {ECO:0000269|PubMed:20577214, ECO:0000269|PubMed:23602659}. |
| Subcellular Location | Cytoplasm. Nucleus. Cell membrane. Note=Translocated from the cytoplasm to the plasma membrane in a CIB1-dependent manner. |
| Tissue Specificity | Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle. {ECO:0000269|PubMed:10802064}. |
| Top Pathways | VEGF signaling pathway, Calcium signaling pathway, Fc gamma R-mediated phagocytosis, Tuberculosis, Sphingolipid signaling pathway |
Human-SPHK1-cDNA-Clone - DC02656 from Abgent, a WuXi AppTec company
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SPHK1 - MBS1267255 from MyBioSource
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SPHK1 - MBS1267000 from MyBioSource
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SPHK1 - MBS1274474 from MyBioSource
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SPHK1 - MBS1265836 from MyBioSource
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Human SPHK1 cDNA clone(NM_001142601.1) - CDFH018485 from Creative Biomart
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Human SPHK1 cDNA clone(NM_001142602.1) - CDFH018486 from Creative Biomart
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human SPHK1 ORF clone - CDCH085246 from Creative Biomart
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human SPHK1 ORF clone - CDCH085247 from Creative Biomart
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Human SPHK1 ORF Clone(NM_001142601.1) - CDCR351376 from Creative Biomart
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Human SPHK1 ORF Clone(NM_001142601.1) - CDCR351377 from Creative Biomart
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Human SPHK1 ORF Clone(NM_001142602.1) - CDCR351378 from Creative Biomart
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Human SPHK1 ORF Clone(NM_001142602.1) - CDCR351512 from Creative Biomart
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human SPHK1 ORF clone - CDCH085252 from Creative Biomart
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human SPHK1 ORF clone - CDCH085253 from Creative Biomart
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human SPHK1 ORF clone - CDCH085254 from Creative Biomart
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human SPHK1 ORF clone - CDCH085255 from Creative Biomart
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human SPHK1 ORF clone - CDCH085256 from Creative Biomart
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human SPHK1 ORF clone - CDCH085257 from Creative Biomart
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human SPHK1 ORF clone - CDCH085258 from Creative Biomart
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human SPHK1 ORF clone - CDCH085259 from Creative Biomart
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human SPHK1 ORF clone - CDCH085260 from Creative Biomart
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human SPHK1 ORF clone - CDCH085261 from Creative Biomart
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Human SPHK1 ORF Clone(NM_021972.3) - CDCL176842 from Creative Biomart
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Human SPHK1 ORF Clone(NM_001142601.1) - CDCL176843 from Creative Biomart
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