SPHK1

Gene Symbol	SPHK1
Entrez Gene	8877
Alt Symbol	SPHK
Species	Human
Gene Type	protein-coding
Description	sphingosine kinase 1
Other Description	SK 1|SPK 1
Swissprots	Q9NYA1 Q9NY70 Q9HD92 Q96GK1 Q8N632 Q9NYL3
Accessions	AAP35060 CAE90363 CAE90969 EAW89388 EAW89389 EAW89390 EAW89391 EAW89392 EAW89393 EAW89394 Q9NYA1 AF200328 AAG01980 AF238083 AAF73423 AF266756 AAF73470 AJ245504 CAB92131 AK022402 BAB14028 AK023393 BAB14558 AK095578 AK122781 BAG53725 AK225250 AK225258 AK292294 BAF84983 AK292614 BAF85303 BC004112 AAH04112 BC008040 AAH08040 BC009419 AAH09419 BC014439 AAH14439 BC030553 AAH30553 BP304783 DC384776 XM_005257766 XP_005257823 XM_011525439 XP_011523741 NM_001142601 NP_001136073 NM_001142602 NP_001136074 NM_021972 NP_068807 NM_182965 NP_892010
Function	Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. {ECO:0000269|PubMed:20577214, ECO:0000269|PubMed:23602659}.
Subcellular Location	Cytoplasm. Nucleus. Cell membrane. Note=Translocated from the cytoplasm to the plasma membrane in a CIB1-dependent manner.
Tissue Specificity	Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle. {ECO:0000269|PubMed:10802064}.
Top Pathways	VEGF signaling pathway, Calcium signaling pathway, Fc gamma R-mediated phagocytosis, Tuberculosis, Sphingolipid signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SPHK / SPHK1 ELISA Kit (Sandwich ELISA) - LS-F8288 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.122 ng/ml Range 0.313-20 ng/ml

Sphingosine Kinase 1/SPHK1 Assay Kit - KA0906 from Novus Biologicals Category Assay Kit Prices $1,139.00 Sizes 1 kit

Human Sphingosine Kinase 1/SPHK1 DuoSet ELISA - DY5536 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 0.312 - 20 ng/mL

Sphingosine Kinase 1 (SPHK1), Human, ELISA Kit - SEE698Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.114ng/mL Range 0.312-20ng/mL

Sphingosine kinase 1, SPHK1, Human, ELISA Kit - E2161h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

SPHK1 (Human) IP-WB Antibody Pair - H00008877-PW2 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

SPHK1 (Human) Matched Antibody Pair - H00008877-AP51 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

SPHK1 Assay Kit - KA0906 from Acris Antibodies Category ELISA Kit

Sphingosine Kinase 1, ELISA Kit - MBS057976 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingosine Kinase 1, ELISA Kit - MBS084093 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingosine Kinase 1, ELISA Kit - MBS071332 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingosine Kinase 1, ELISA Kit - MBS096458 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingosine Kinase 1, ELISA Kit - MBS075746 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingosine Kinase 1, ELISA Kit - MBS101108 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingosine Kinase 1, ELISA Kit - MBS056367 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/ml Range 0.625 ng/ml - 20 ng/ml

SPHK1, ELISA Kit - MBS2516198 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

ELISA Kit for Sphingosine Kinase 1 (SPHK1) - SEE698Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.122ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human SPHK / SPHK1 ELISA Kit (Custom ELISA) - LS-F19388 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.313-20 ng/ml

Rat SPHK / SPHK1 ELISA Kit (Custom ELISA) - LS-F19390 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.313-20 ng/ml

Mouse SPHK / SPHK1 ELISA Kit (Custom ELISA) - LS-F19389 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.313-20 ng/ml

Human Sphingosine Kinase 1 (SPHK1) ELISA Kit - EKU07437 from Biomatik Category ELISA Kit Prices $735.00, $3,234.00, $5,880.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.122 ng/mL Range 0.312-20 ng/mL

Human SPHK1(Sphingosine Kinase 1) ELISA Kit - E-EL-H2582 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.19 ng/mLng/mL Range 0.31~20 ng/mL

Human Sphingosine Kinase 1 ELISA Kit - abx153152 from Abbexa Category ELISA Kit Sensitivity 0.117 ng/ml Range 0.313 ng/ml - 20 ng/ml

Human SPHK / SPHK1 ELISA Kit (Sandwich ELISA) - LS-F22207 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 0.188 ng/ml Range 0.313-20 ng/ml

Human SPHK1(Sphingosine Kinase 1) ELISA Kit - E-EL-H2582 from Elabscience Category ELISA Kit Sensitivity 0.19 ng/mL Range 0.31—20 ng/mL

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