SPHK1

Gene Symbol SPHK1
Entrez Gene 8877
Alt Symbol SPHK
Species Human
Gene Type protein-coding
Description sphingosine kinase 1
Other Description SK 1|SPK 1
Swissprots Q9NYA1 Q9NY70 Q9HD92 Q96GK1 Q8N632 Q9NYL3
Accessions AAP35060 CAE90363 CAE90969 EAW89388 EAW89389 EAW89390 EAW89391 EAW89392 EAW89393 EAW89394 Q9NYA1 AF200328 AAG01980 AF238083 AAF73423 AF266756 AAF73470 AJ245504 CAB92131 AK022402 BAB14028 AK023393 BAB14558 AK095578 AK122781 BAG53725 AK225250 AK225258 AK292294 BAF84983 AK292614 BAF85303 BC004112 AAH04112 BC008040 AAH08040 BC009419 AAH09419 BC014439 AAH14439 BC030553 AAH30553 BP304783 DC384776 XM_005257766 XP_005257823 XM_011525439 XP_011523741 NM_001142601 NP_001136073 NM_001142602 NP_001136074 NM_021972 NP_068807 NM_182965 NP_892010
Function Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. {ECO:0000269|PubMed:20577214, ECO:0000269|PubMed:23602659}.
Subcellular Location Cytoplasm. Nucleus. Cell membrane. Note=Translocated from the cytoplasm to the plasma membrane in a CIB1-dependent manner.
Tissue Specificity Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle. {ECO:0000269|PubMed:10802064}.
Top Pathways VEGF signaling pathway, Calcium signaling pathway, Fc gamma R-mediated phagocytosis, Tuberculosis, Sphingolipid signaling pathway

SPHK1-Over-expression-Lysate - LY10649a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag SPHK1 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the SPHK1 gene

SPHK1 293T Cell Transient Overexpression Lysate(Denatured) - H00008877-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

SPHK1 overexpression lysate - LY405282 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

SPHK1 overexpression lysate - LY411847 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

Sphingosine Kinase 1/SPHK1 Overexpression Lysate (Denatured) - H00008877-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
Lane 1: SPHK1 transfected lysate (43.9 KDa) Lane 2: Non-transfected lysate.

Sphingosine Kinase 1/SPHK1 Overexpression Lysate (Native) - NBP2-06490 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Sphingosine Kinase 1 Overexpression Lysate (Adult Normal) [NBP2-06490] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Sphingosine Kinase 1.

Human SPHK1 / Sphingosine Kinase 1 Insect Cell Lysate (WB positive control) - 15679-HNCBL-300 from Sino Biological

Category Cell Lysate
Prices $195.00
Sizes 300 µg
Species Human

Human SPHK1 / Sphingosine Kinase 1 Insect Cell Lysate (WB positive control) - 15679-H20BL-300 from Sino Biological

Category Cell Lysate
Prices $195.00
Sizes 300 µg
Species Human

Human SPHK1 Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175313 from Biorbyt

Category Cell Lysate
Prices $425.00
Sizes 300 μg
Species Human

Sphingosine Kinase 1/SPHK1 Overexpression Lysate (Denatured) - H00008877-T02 from Novus Biologicals

Category Cell Lysate
Prices $299.00
Sizes 100 µl

Human SPHK1 Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175317 from Biorbyt

Category Cell Lysate
Prices $604.00
Sizes 300 μg
Species Human

Panoply™ Human SPHK1 Knockdown Stable Cell Line - CSC-DC015041 from Creative biogene

Category Cell Line
Species Human
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