| Gene Symbol | APLF |
|---|---|
| Entrez Gene | 200558 |
| Alt Symbol | APFL, C2orf13, PALF, Xip1, ZCCHH1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | aprataxin and PNKP like factor |
| Other Description | PNK and APTX-like FHA domain-containing protein|PNK and APTX-like FHA protein|XRCC1-interacting protein 1|aprataxin and PNK-like factor|aprataxin- and PNK-like factor|apurinic-apyrimidinic endonuclease APLF|zinc finger, CX5CX6HX5H motif containing 1 |
| Swissprots | Q53P47 Q53PB9 A8K476 Q8IW19 Q53QU0 |
| Accessions | AAY14945 AAY24008 AAY24113 EAW99871 EAW99872 Q8IW19 AK290841 BAF83530 AK308186 BC030711 BC041144 AAH41144 DA641644 NM_173545 NP_775816 |
| Function | Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic- apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage. {ECO:0000269|PubMed:17353262, ECO:0000269|PubMed:17396150}. |
| Subcellular Location | Nucleus. Cytoplasm, cytosol. Note=Localizes to DNA damage sites. Accumulates at single-strand breaks and double-strand breaks via the PBZ-type zinc fingers. |