APLF

Gene Symbol	APLF
Entrez Gene	200558
Alt Symbol	APFL, C2orf13, PALF, Xip1, ZCCHH1
Species	Human
Gene Type	protein-coding
Description	aprataxin and PNKP like factor
Other Description	PNK and APTX-like FHA domain-containing protein|PNK and APTX-like FHA protein|XRCC1-interacting protein 1|aprataxin and PNK-like factor|aprataxin- and PNK-like factor|apurinic-apyrimidinic endonuclease APLF|zinc finger, CX5CX6HX5H motif containing 1
Swissprots	Q53P47 Q53PB9 A8K476 Q8IW19 Q53QU0
Accessions	AAY14945 AAY24008 AAY24113 EAW99871 EAW99872 Q8IW19 AK290841 BAF83530 AK308186 BC030711 BC041144 AAH41144 DA641644 NM_173545 NP_775816
Function	Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic- apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage. {ECO:0000269|PubMed:17353262, ECO:0000269|PubMed:17396150}.
Subcellular Location	Nucleus. Cytoplasm, cytosol. Note=Localizes to DNA damage sites. Accumulates at single-strand breaks and double-strand breaks via the PBZ-type zinc fingers.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

APLF (N-16) - sc-161354 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-APLF antibody - ab79371 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-APLF antibody - ab196502 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-APLF antibody - ab105446 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-APLF antibody - C-terminal - ab197841 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-APLF / PALF Antibody (phospho-Ser116) - LS-C291197 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-APLF / PALF Antibody (C-Terminus) - LS-C151935 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-APLF / PALF Antibody (aa82-131) - LS-C118348 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

APLF Antibody - NBP2-38212 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

APLF Antibody - NBP1-86806 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

APLF Polyclonal Antibody - bs-12489R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

APLF Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-12489R-A350 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

APLF Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-12489R-A488 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

APLF Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-12489R-A555 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

APLF Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-12489R-A647 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

APLF Polyclonal Antibody, Cy3 Conjugated - bs-12489R-Cy3 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

APLF Polyclonal Antibody, Cy5 Conjugated - bs-12489R-Cy5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

APLF Polyclonal Antibody, Cy5.5 Conjugated - bs-12489R-Cy5.5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

APLF Polyclonal Antibody, Cy7 Conjugated - bs-12489R-Cy7 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

APLF Polyclonal Antibody, FITC Conjugated - bs-12489R-FITC from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

APLF Polyclonal Antibody, Biotin Conjugated - bs-12489R-Biotin from Bioss Prices $349.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

APLF Polyclonal Antibody, HRP Conjugated - bs-12489R-HRP from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-APLF (451-465) antibody produced in rabbit - SAB1103546 from Sigma-Aldrich Prices $298.50 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-APLF antibody produced in rabbit - HPA034643 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-APLF (391-405) antibody produced in rabbit - SAB1103545 from Sigma-Aldrich Prices $298.50 Sizes 200 µl Host Rabbit Clonality Polyclonal

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