| Gene Symbol | IL33 |
|---|---|
| Entrez Gene | 90865 |
| Alt Symbol | C9orf26, DVS27, IL1F11, NF-HEV, NFEHEV |
| Species | Human |
| Gene Type | protein-coding |
| Description | interleukin 33 |
| Other Description | DVS27-related protein|IL-1F11|IL-33|interleukin-1 family member 11|interleukin-33|nuclear factor for high endothelial venules|nuclear factor from high endothelial venules |
| Swissprots | B4E1Q9 B2R8L1 O95760 E7EAX4 B4DJ35 Q2YEJ5 D3DRI5 |
| Accessions | EAW58748 EAW58749 EAW58750 EAW58751 O95760 AB024518 BAA75892 AI610794 AK295908 BAG58697 AK303943 BAG64871 AK313414 BAG36208 AL080211 AY905581 AAX86998 BC047085 AAH47085 BQ878541 CR407619 CAG28547 DB477860 HQ641439 ADR77828 XM_005251626 XP_005251683 XM_005251627 XP_005251684 XM_011518059 XP_011516361 XM_011518060 XP_011516362 XM_011518061 XP_011516363 NM_001199640 NP_001186569 NM_001199641 NP_001186570 NM_033439 NP_254274 |
| Function | Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528). {ECO:0000269|PubMed:16286016, ECO:0000269|PubMed:17853410, ECO:0000269|PubMed:18836528}. |
| Subcellular Location | Nucleus. Chromosome. Cytoplasmic vesicle, secretory vesicle. Secreted. Note=Associates with heterochromatin and mitotic chromosomes. Translocation from the nucleus occurs upon biomechanical strain, depends on an intact microtubule network, and is ATP-dependent. |
| Tissue Specificity | Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta. {ECO:0000269|PubMed:12819012}. |
| Top Pathways | Cytosolic DNA-sensing pathway, Influenza A |
IL-33 CRISPR/Cas9 KO Plasmid (h) - sc-417699 from Santa Cruz Biotechnology
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IL-33 HDR Plasmid (h) - sc-417699-HDR from Santa Cruz Biotechnology
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IL-33 Double Nickase Plasmid (h) - sc-417699-NIC from Santa Cruz Biotechnology
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IL-33 Double Nickase Plasmid (h2) - sc-417699-NIC-2 from Santa Cruz Biotechnology
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IL-33 CRISPR Activation Plasmid (h) - sc-417699-ACT from Santa Cruz Biotechnology
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IL-33 CRISPR Activation Plasmid (h2) - sc-417699-ACT-2 from Santa Cruz Biotechnology
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IL-33 Lentiviral Activation Particles (h) - sc-417699-LAC from Santa Cruz Biotechnology
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IL-33 Lentiviral Activation Particles (h2) - sc-417699-LAC-2 from Santa Cruz Biotechnology
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IL-33 siRNA (h) - sc-75333 from Santa Cruz Biotechnology
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IL-33 shRNA Plasmid (h) - sc-75333-SH from Santa Cruz Biotechnology
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IL-33 shRNA (h) Lentiviral Particles - sc-75333-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU008491 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10630 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10630 from Sigma-Aldrich
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IL33 siRNA (Human) - CRJ3994 from Cohesion Biosciences
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IL33 - MBS8200220 from MyBioSource
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shRNA set against Human IL33 (NM_033439.3) - SHH318925 from Creative biogene
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Human IL33 siRNA - orb274495 from Biorbyt
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IL33 shRNA Plasmid (Human) - CHJ3994 from Cohesion Biosciences
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IL33 miRNA 3'UTR clone - MiUTR3H-10147 from Creative biogene
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