IL33

Gene Symbol	IL33
Entrez Gene	90865
Alt Symbol	C9orf26, DVS27, IL1F11, NF-HEV, NFEHEV
Species	Human
Gene Type	protein-coding
Description	interleukin 33
Other Description	DVS27-related protein\|IL-1F11\|IL-33\|interleukin-1 family member 11\|interleukin-33\|nuclear factor for high endothelial venules\|nuclear factor from high endothelial venules
Swissprots	B4E1Q9 B2R8L1 O95760 E7EAX4 B4DJ35 Q2YEJ5 D3DRI5
Accessions	EAW58748 EAW58749 EAW58750 EAW58751 O95760 AB024518 BAA75892 AI610794 AK295908 BAG58697 AK303943 BAG64871 AK313414 BAG36208 AL080211 AY905581 AAX86998 BC047085 AAH47085 BQ878541 CR407619 CAG28547 DB477860 HQ641439 ADR77828 XM_005251626 XP_005251683 XM_005251627 XP_005251684 XM_011518059 XP_011516361 XM_011518060 XP_011516362 XM_011518061 XP_011516363 NM_001199640 NP_001186569 NM_001199641 NP_001186570 NM_033439 NP_254274
Function	Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528). {ECO:0000269\|PubMed:16286016, ECO:0000269\|PubMed:17853410, ECO:0000269\|PubMed:18836528}.
Subcellular Location	Nucleus. Chromosome. Cytoplasmic vesicle, secretory vesicle. Secreted. Note=Associates with heterochromatin and mitotic chromosomes. Translocation from the nucleus occurs upon biomechanical strain, depends on an intact microtubule network, and is ATP-dependent.
Tissue Specificity	Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta. {ECO:0000269\|PubMed:12819012}.
Top Pathways	Cytosolic DNA-sensing pathway, Influenza A

IL-33 (D-19) - sc-83411 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

IL-33 (H-226) - sc-98659 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

IL-33 (H-226): sc-98659. Western blot analysis of IL-33 expression in Jurkat (A), HeLa (B), T84 (C) and A549 (D) whole cell lysates and HeLa (E) and Jurkat (F) nuclear extracts.

IL-33 (4E9) - sc-130625 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	50 µg/500 µl
Host	Mouse
Clonality	Monoclonal

IL-33 (4E9): sc-130625. Western blot analysis of IL-33 expression in Jurkat whole cell lysate.

Anti-IL33 antibody - ab118503 from Abcam

Prices	$378.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Human Uterus, Vessels (formalin-fixed, paraffin-embedded) stained with IL33 antibody ab118503 at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-IL33 antibody - ab83873 from Abcam

Prices	$376.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-IL33 antibody (ab83873) at 1 µg/ml + 293T cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-IL33 antibody - ab110535 from Abcam

Prices	$370.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-IL33 antibody - ab90078 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-IL33 antibody (ab90078) at 1 µg/ml + Lymph node (Human) Tissue Lysate - adult normal tissue (ab29871) at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-IL33 antibody - ab92822 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-IL33 antibody (ab92822) + Recombinant human IL33 (100-145)

Anti-IL33 antibody - ab174760 from Abcam

Prices	$376.00
Sizes	200 µl
Host	Goat
Clonality	Polyclonal

Anti-IL33 antibody (ab174760) at 1 µg + Jurkat lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-IL33 antibody - ab166979 from Abcam

Host	Sheep
Clonality	Polyclonal

Anti-IL33 antibody [1H1L9] - ab200481 from Abcam

Prices	$359.00
Sizes	100 µg
Host	Rabbit
Clonality	Monoclonal
Clone	1H1L9

Anti-IL33 antibody [1H1L9] (ab200481) at 1 µg/ml + Active recombinant Human IL33 proteindeveloped using the ECL technique

Anti-IL33 antibody [4E9] - ab72844 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	4E9

Anti-IL33 antibody [4E9] (ab72844) at 1/500 dilution + Jurkat cell lysate at 35 µgSecondarygoat anti-mouse secondary antibody conjugated to HRP developed using the ECL technique

Anti-IL33 antibody (Biotin) - ab84249 from Abcam

Prices	$370.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-IL33 antibody (HRP) - ab106022 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-IL33 antibody (HRP) (ab106022) at 1/5000 dilution + Recombinant Human IL33

Anti-IL33 antibody [Nessy-1] - ab54385 from Abcam

Prices	$378.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal
Clone	Nessy-1

All lanes : Anti-IL33 antibody [Nessy-1] (ab54385) at 1/1000 dilutionLane 1 : Liver LysateLane 2 : Liver Cell LysateLysates/proteins at 25 µg per lane.SecondaryGoat anti-mouse HRP conjugated polyclonal antibody at 1/1000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-IL33 antibody [Nessy-1] (Biotin) - ab54384 from Abcam

Prices	$378.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal
Clone	Nessy-1

Skin biopsy samples from patients with psoriasis and control subjects were immediately placed in Tissue Freezing Medium and stored at-80 °C. Five sections (5 µm) were cut using a cryostat and fixed with cold acetone for 10 minutes. Immunohistochemical staining was performed using a LSAB+ system kit. Incubation with ab54384 at 1/100 dilution was performed for 30 minutes; secondary antibody was provided in the kit and was also used for 30 minutes, followed by appropriate washes. As negative control, the primary antibody was omitted.

Anti-IL-33 Antibody - LS-C37003 from LifeSpan Bioscience

Prices	$605.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Anti-IL-33 Antibody - LS-C37004 from LifeSpan Bioscience

Prices	$665.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Anti-IL-33 Antibody - LS-C56927 from LifeSpan Bioscience

Prices	$450.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-IL-33 Antibody (aa1-108) - LS-C125797 from LifeSpan Bioscience

Prices	$465.00
Sizes	100 µg
Host	Rat
Clonality	Monoclonal

Anti-IL-33 Antibody (Biotin) - LS-C104696 from LifeSpan Bioscience

Prices	$285.00, $325.00
Sizes	25 µg, 50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-IL-33 Antibody (aa50-100) - LS-C47355 from LifeSpan Bioscience

Prices	$335.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of human IL-33inHUVEC cell lysate in the 1) absence and 2) presence of immunizing peptide using antibody at1 ug/ml.

Anti-IL-33 Antibody (Biotin) - LS-C154115 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-IL-33 Antibody (aa112-270, clone 12K111, PE) - LS-C182884 from LifeSpan Bioscience

Prices	$575.00
Sizes	100 tst
Host	Rat
Clonality	Monoclonal
Clone	12K111

Anti-IL-33 Antibody (aa112-270, clone 12K111, APC) - LS-C182885 from LifeSpan Bioscience

Prices	$635.00
Sizes	100 tst
Host	Rat
Clonality	Monoclonal
Clone	12K111

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