| Gene Symbol |
IL33
|
| Entrez Gene |
90865
|
| Alt Symbol |
C9orf26, DVS27, IL1F11, NF-HEV, NFEHEV
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interleukin 33
|
| Other Description |
DVS27-related protein|IL-1F11|IL-33|interleukin-1 family member 11|interleukin-33|nuclear factor for high endothelial venules|nuclear factor from high endothelial venules
|
| Swissprots |
B4E1Q9 B2R8L1 O95760 E7EAX4 B4DJ35 Q2YEJ5 D3DRI5
|
| Accessions |
EAW58748 EAW58749 EAW58750 EAW58751 O95760 AB024518 BAA75892 AI610794 AK295908 BAG58697 AK303943 BAG64871 AK313414 BAG36208 AL080211 AY905581 AAX86998 BC047085 AAH47085 BQ878541 CR407619 CAG28547 DB477860 HQ641439 ADR77828 XM_005251626 XP_005251683 XM_005251627 XP_005251684 XM_011518059 XP_011516361 XM_011518060 XP_011516362 XM_011518061 XP_011516363 NM_001199640 NP_001186569 NM_001199641 NP_001186570 NM_033439 NP_254274
|
| Function |
Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528). {ECO:0000269|PubMed:16286016, ECO:0000269|PubMed:17853410, ECO:0000269|PubMed:18836528}.
|
| Subcellular Location |
Nucleus. Chromosome. Cytoplasmic vesicle, secretory vesicle. Secreted. Note=Associates with heterochromatin and mitotic chromosomes. Translocation from the nucleus occurs upon biomechanical strain, depends on an intact microtubule network, and is ATP-dependent.
|
| Tissue Specificity |
Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta. {ECO:0000269|PubMed:12819012}.
|
| Top Pathways |
Cytosolic DNA-sensing pathway, Influenza A
|
![Western Blot: IL33 Overexpression Lysate (Adult Normal) [NBL1-11954] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for IL33.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/12181_IL33%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-11954-img0002.jpg)