IL33

Gene Symbol	IL33
Entrez Gene	90865
Alt Symbol	C9orf26, DVS27, IL1F11, NF-HEV, NFEHEV
Species	Human
Gene Type	protein-coding
Description	interleukin 33
Other Description	DVS27-related protein|IL-1F11|IL-33|interleukin-1 family member 11|interleukin-33|nuclear factor for high endothelial venules|nuclear factor from high endothelial venules
Swissprots	B4E1Q9 B2R8L1 O95760 E7EAX4 B4DJ35 Q2YEJ5 D3DRI5
Accessions	EAW58748 EAW58749 EAW58750 EAW58751 O95760 AB024518 BAA75892 AI610794 AK295908 BAG58697 AK303943 BAG64871 AK313414 BAG36208 AL080211 AY905581 AAX86998 BC047085 AAH47085 BQ878541 CR407619 CAG28547 DB477860 HQ641439 ADR77828 XM_005251626 XP_005251683 XM_005251627 XP_005251684 XM_011518059 XP_011516361 XM_011518060 XP_011516362 XM_011518061 XP_011516363 NM_001199640 NP_001186569 NM_001199641 NP_001186570 NM_033439 NP_254274
Function	Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528). {ECO:0000269|PubMed:16286016, ECO:0000269|PubMed:17853410, ECO:0000269|PubMed:18836528}.
Subcellular Location	Nucleus. Chromosome. Cytoplasmic vesicle, secretory vesicle. Secreted. Note=Associates with heterochromatin and mitotic chromosomes. Translocation from the nucleus occurs upon biomechanical strain, depends on an intact microtubule network, and is ATP-dependent.
Tissue Specificity	Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta. {ECO:0000269|PubMed:12819012}.
Top Pathways	Cytosolic DNA-sensing pathway, Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

IL-33 (Interleukin-33) Human ELISA Kit - ab119547 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity 0.2 pg/ml Range 7.8 pg/ml - 500 pg/ml

Human IL-33 ELISA Kit (Sandwich ELISA) - LS-F2765 from LifeSpan Bioscience Category ELISA Kit Prices $490.00 Sizes 1 plate Sensitivity 10 pg/ml Range 2.048-200 pg/ml

Mouse IL-33 ELISA Kit (Sandwich ELISA) - LS-F2766 from LifeSpan Bioscience Category ELISA Kit Prices $490.00 Sizes 1 plate Sensitivity 10 pg/ml Range 2.048-200 pg/ml

Mouse IL-33 ELISA Kit (Sandwich ELISA) - LS-F5697 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 2.5 pg/ml Range 2.048-200 pg/ml

Human IL-33 ELISA Kit (Sandwich ELISA) - LS-F5802 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 6 pg/ml Range 2.048-200 pg/ml

Mouse IL-33 ELISA Kit (Sandwich ELISA) - LS-F388 from LifeSpan Bioscience Category ELISA Kit Prices $600.00, $1,100.00, $2,520.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 2.048 pg/ml Range 2.048-200 pg/ml

Human IL-33 ELISA Kit (Sandwich ELISA) - LS-F127 from LifeSpan Bioscience Category ELISA Kit Prices $520.00, $930.00, $2,140.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 2.048 pg/ml Range 2.048-200 pg/ml

Human IL-33 ELISA Kit (Sandwich ELISA) - LS-F579 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 2.048-200 pg/ml

Mouse IL-33 ELISA Kit (Sandwich ELISA) - LS-F669 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 2.048-200 pg/ml

Rat IL-33 ELISA Kit (Sandwich ELISA) - LS-F7871 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 2.8 pg/ml Range 2.048-200 pg/ml

Human IL-33 ELISA Kit (Sandwich ELISA) - LS-F11789 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 15.6 Range 2.048-200 pg/ml

Rat IL-33 ELISA Kit (Sandwich ELISA) - LS-F11788 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 31.2 Range 2.048-200 pg/ml

Human IL-33 ELISA Kit - RAB0297 from Sigma-Aldrich Category ELISA Kit Prices $608.00 Sizes 1 kt

Human IL-33 HS Magnetic Luminex Performance Assay - LBHS3625 from R&D Systems

Human IL-33 DuoSet ELISA, 15 Plate - DY3625 from R&D Systems Category ELISA Kit Prices $249.00, $649.00 Sizes 1 kit (for 5 Plates), 1 kit (for 15 Plates) Range 23.40 - 1,500 pg/mL

Mouse/Rat IL-33 Quantikine ELISA Kit - M3300 from R&D Systems Category ELISA Kit Prices $479.00 Sizes 1 kit Sensitivity 14.3 pg/mL Range 31.2 - 2,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma)

Mouse IL-33 DuoSet ELISA - DY3626 from R&D Systems Category ELISA Kit Prices $249.00, $649.00 Sizes 1 kit (for 5 Plates), 1 kit (for 15 Plates) Range 15.60 - 1,000 pg/mL

Human IL-33 Quantikine ELISA Kit - D3300 from R&D Systems Category ELISA Kit Prices $519.00 Sizes 1 kit Sensitivity 1.65 pg/mL Range 6.3 - 400 pg/mL (Cell Culture Supernates, Cell Lysates, Serum, EDTA Plasma, Heparin Plasma)

Human IL-33 DuoSet, 5 Plate - DY3625-05 from R&D Systems Category ELISA Kit

Mouse IL-33 DuoSet, 5 Plate - DY3626-05 from R&D Systems Category ELISA Kit

Quantikine Immunoassay Control Set 790 for Human IL-33 - QC30 from R&D Systems Category ELISA Kit Prices $125.00 Sizes 1 each

IL-33 ELISA Kit (Human) : 96 Wells (OKAG00038) - OKAG00038 from Aviva Systems Biology Category ELISA Kit Prices $390.00 Sizes 96 wells Sensitivity 32 pg/mL Range 32-4,000 pg/mL

Human IL-33 ELISA Kit - abx056233 from Abbexa Category ELISA Kit

Human Interleukin 33 ELISA Kit - abx052291 from Abbexa Category ELISA Kit

Human Interleukin 33 ELISA Kit - abx152042 from Abbexa Category ELISA Kit Sensitivity 6.6 pg/ml Range 15.625 pg/ml - 1000 pg/ml

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