| Gene Symbol | NFKBIA |
|---|---|
| Entrez Gene | 4792 |
| Alt Symbol | IKBA, MAD-3, NFKBI |
| Species | Human |
| Gene Type | protein-coding |
| Description | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
| Other Description | I-kappa-B-alpha|IkappaBalpha|NF-kappa-B inhibitor alpha|ikB-alpha|major histocompatibility complex enhancer-binding protein MAD3|nuclear factor of kappa light chain gene enhancer in B-cells |
| Swissprots | B2R8L6 P25963 |
| Accessions | AAD14949 AAR29599 CAB65110 CAB65111 CAB65112 CAB65113 CAB65114 CAB65556 CAM91165 CBX47574 EAW65875 P25963 AK311515 AK313421 BAG36213 AY033600 AAK51149 BC002601 AAH02601 BC004983 AAH04983 BT007091 AAP35754 BU737609 M69043 AAA16489 NM_020529 NP_065390 |
| Function | Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. {ECO:0000269|PubMed:7479976}. |
| Subcellular Location | Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export. {ECO:0000250}. |
| Top Pathways | Legionellosis, Herpes simplex infection, Viral carcinogenesis, Influenza A, Epstein-Barr virus infection |