Gene Symbol | HSF1 |
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Entrez Gene | 3297 |
Alt Symbol | HSTF1 |
Species | Human |
Gene Type | protein-coding |
Description | heat shock transcription factor 1 |
Other Description | HSF 1|HSTF 1|heat shock factor protein 1 |
Swissprots | A8MW26 A8K4L0 Q53XT4 Q00613 |
Accessions | CAM91162 EAW82131 Q00613 AF299094 AAG23698 AK054762 BAG51421 AK125467 BAG54202 AK126580 AK222497 BAD96217 AK290975 BAF83664 AK300205 BAG61976 BC014638 AAH14638 BT007351 AAP36015 DA481620 DQ893859 ABM84785 M64673 AAA52695 XM_005272315 XP_005272372 XM_005272316 XP_005272373 XM_005272317 XP_005272374 XM_011517004 XP_011515306 XM_011517005 XP_011515307 XM_011517006 XP_011515308 XR_246618 NM_005526 NP_005517 |
Function | DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. {ECO:0000269|PubMed:11447121, ECO:0000269|PubMed:11583998, ECO:0000269|PubMed:12659875, ECO:0000269|PubMed:12665592, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:8946918, ECO:0000269|PubMed:9121459, ECO:0000269|PubMed:9535852}. |
Subcellular Location | Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth. On activation, translocates to nuclear stress granules. Colocalizes with SUMO1 in nuclear stress granules. |
Top Pathways | Legionellosis |
HSF1 CRISPR/Cas9 KO Plasmid (h) - sc-400432 from Santa Cruz Biotechnology
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HSF1 HDR Plasmid (h) - sc-400432-HDR from Santa Cruz Biotechnology
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HSF1 Double Nickase Plasmid (h) - sc-400432-NIC from Santa Cruz Biotechnology
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HSF1 Double Nickase Plasmid (h2) - sc-400432-NIC-2 from Santa Cruz Biotechnology
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HSF1 CRISPR Activation Plasmid (h) - sc-400432-ACT from Santa Cruz Biotechnology
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HSF1 CRISPR Activation Plasmid (h2) - sc-400432-ACT-2 from Santa Cruz Biotechnology
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HSF1 Lentiviral Activation Particles (h) - sc-400432-LAC from Santa Cruz Biotechnology
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HSF1 Lentiviral Activation Particles (h2) - sc-400432-LAC-2 from Santa Cruz Biotechnology
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HSF1 siRNA (h) - sc-35611 from Santa Cruz Biotechnology
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HSTF1 shRNA Plasmid (h) - sc-35611-SH from Santa Cruz Biotechnology
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HSTF1 shRNA (h) Lentiviral Particles - sc-35611-V from Santa Cruz Biotechnology
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HSF1 RNAi - H00003297-R01 from Novus Biologicals
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MISSION® esiRNA - EHU107721 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2298 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2298 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03124 from Sigma-Aldrich
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HSF1 siRNA (Human) - CRH2253 from Cohesion Biosciences
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HSF1 - MBS8201711 from MyBioSource
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shRNA set against Human HSF1 (NM_005526.2) - SHH315365 from Creative biogene
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Human HSF1 siRNA - orb262755 from Biorbyt
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HSF1 shRNA Plasmid (Human) - CHH2253 from Cohesion Biosciences
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HSF1 miRNA 3'UTR clone - MiUTR1H-04721 from Creative biogene
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